This study assessed the heavy metals and polycyclic aromatic hydrocarbons (PAHs) pollutant in soil around petrol filling stations automobile mechanic workshops. Samples of were acquired from depth range 0–15 cm. Toxic analyzed with atomic absorption spectrophotometry. The PAHs using phytochemical chromatographic analysis by Soxhlet extraction method. tested was weakly acidic (6.12–6.81). trend ...

The chalcone analog E,E-bis(2-hydroxybenzylidene)acetone (HBA) was found to display strong NAD(P)H:quinone reductase (NQO1) inducer potency in Hepa 1c1c7 cells. In order to determine whether this promising chemopreventive activity would extend to anticarcinogenic properties, the effect of HBA on the 7,12-dimethylbenz[a]anthracene (DMBA)-induced expression of the Ha-ras gene in isolated RNA from...

PURPOSE Synthetic progestins are widely used therapeutically; however, there is controversy regarding their proliferative effects. We used a rat 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumor model to test the hypothesis that progestins increase angiogenesis and as a result decrease the latency period and increase the multiplicity of mammary tumors. EXPERIMENTAL DESIGN Medroxypro...

Several of the priority pollutants discussed in EPA's Ambient Water Quality Criteria documents have been reported to have promotion or cocarcinogenic activity. For example, phenol appears to have tumor-promoting activity in mice when repeatedly applied after initiation with either 7,12-dimethyl-1,2-benzanthracene (DMBA) or benzo(a)pyrene (BaP). Similarly, it has been reported that 2,3,7,8-tetra...

The formation of epidermal DNA adducts from 9-fluoro-7,12-dimethylbenz(a)anthracene (9-F-DMBA) was compared with 7,12-dimethylbenz(a)anthracene (DMBA) and 10-fluoro-7,12-dimethylbenz(a)anthracene (10-F-DMBA) in SENCAR mice. 9-F-DMBA is equipotent, whereas 10-F-DMBA is more potent than DMBA for skin tumor initiation in this mouse stock. The quantity of covalently bound DNA adducts was essentiall...

This study assessed the heavy metals and polycyclic aromatic hydrocarbons (PAHs) pollutant in soil around petrol filling stations automobile mechanic workshops. Samples of were acquired from depth range 0–15 cm. Toxic analyzed with atomic absorption spectrophotometry. The PAHs using phytochemical chromatographic analysis by Soxhlet extraction method. tested was weakly acidic (6.12–6.81). trend ...

The effects of hyperbaric oxygen (HBO) on mouse skin two-stage chemical carcinogenesis were examined. Six-week-old inbred CD-1 female mice were divided into the following five groups: group 1, normoxia and application of 25 nmol 7,12-dimethylbenz[a]anthracene (DMBA) and 8.5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) (n=19); group 2, HBO and DMBA/TPA (n=21); group 3, HBO and DMBA/acetone (n...

Abstract. Rate coefficients for the reaction of NO3 radicals with a series aromatic aldehydes were measured in 7300 L simulation chamber at ambient temperature and pressure by relative absolute methods. The rate benzaldehyde (BA), ortho-tolualdehyde (O-TA), meta-tolualdehyde (M-TA), para-tolualdehyde (P-TA), 2,4-dimethyl (2,4-DMBA), 2,5-dimethyl (2,5-DMBA) 3,5-dimethyl (3,5-DMBA) k1= 2.6 ± 0.3,...