Herein is reported a Rh2(OAc)4/IMes ? HCl system that promotes the chemoselective installation of aryl groups at 2-position furo[2,3-b]pyridine (53–94% yields). The method applicable to direct modification natural furoquinoline alkaloid dictamnine. cardiac effects fluorinated analogues improved, compared dictamnine 160 ?g/mL. Preliminary mechanism action studies indicate might be related epinep...

Benzoquinone (BQ) and O(2) are among the most common stoichiometric oxidants in Pd-catalyzed oxidation reactions. The present study provides rare insights into mechanistic differences between BQ and O(2) in their reactivity with a well-defined Pd-hydride complex, Pd(IMes)(2)(H)(O(2)CPh) (1). BQ promotes the reductive elimination of PhCO(2)H from 1 and catalyzes the formation of a Pd(II)-OOH com...

We prove the case t = 2 of a conjecture Bruns-Conca-Varbaro, describing minimal relations between x minors generic matrix. Interpreting these as polynomial functors, and applying transpose duality in work Sam-Snowden, this problem is equivalent to understanding satisfied by generalized permanents. Our proof follows combining Koszul homology calculations on side, with study subspace varieties pe...