This study examines the pyrolysis products of smoked methamphetamine mixed with tobacco that was trapped with a C8 adsorbent cartridge and then detected by gas chromatography-tandem mass spectrometry. According to the results, the mainstream smoke contains 2-methylpropyl-benzene, 2-chloropropyl-benzene, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, 3-ethyl-phenol, methamphetamine, dimethyl...

Inflammasome plays a critical role in psoriasis. Therefore, targeting NLRP3 inflammasome may be useful strategy to treat In this study, we found that 1-methylpropyl 2-imidazolyl disulfide (PX-12) had potential inhibitory effects on imiquimod (IMQ)-induced IL-1β and IL-18 secretion as well pyroptotic cell death lipopolysaccharide (LPS)-primed THP-1 macrophages. PX-12 also inhibited the release o...

A general strategy to determine enthalpies of formation of protic ionic liquids, based solely on enthalpy of solution measurements, was conceived and tested for 1-methylimidazolium ethanoate, leading to Δ(f)H°(m){[Hmim][O(2)CCH(3)], 1} = -(425.7 ± 1.2) kJ mol(-1). This result in conjunction with the enthalpy of formation of gaseous 1-methylimidazole (mim) proposed in this work, Δ(f)H°(m)(mim, g...

2-[(1-methylpropyl)dithio]-1H-imidazole (IV-2) is a known inhibitor of the thioredoxin system. It causes the oxidation of cysteine residues from both thioredoxin reductase and thioredoxin, with only the latter leading to irreversible inhibition of protein function. Although IV-2 is considered to be the first specific inhibitor of thioredoxin to undergo evaluation in cancer patients (under the n...

Pollution of aquatic bodies by pharmaceutical compounds is an emerging environmental problem because these drugs are extensively used in animal and human medicine. Ibuprofen, 2-[4-(2-methylpropyl)phenyl] propanoic acid, the non-steroidal anti-inflammatory drug mainly present both wastewater rivers lakes Europe. Despite this emergency giving rise a great interest scientific community, literature...