Hurting the virus by targeting host Many proteins play a role in life cycle of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and some are required for viral replication translation. There efforts toward finding drugs that target proteins, but complementary approach is to these proteins. White et al. explored antiviral activity cyclic depsipeptide drug plitidepsin, which targets ...

background: lipopolysaccharides (lpss) and several antigenic proteins of brucella have been considered for preparation of diagnostic reagents and subunit vaccines. the objective of this study was to identify and compare immunogens of b. abortus s19 which induce humoral immune responses in human, goat and rabbit.   material and methods: the bacterial whole cell extract was prepared in extraction...

phosphate (p) is one of the key substrates in energy metabolism and biosynthesis of nucleic acids and membranes. in order to identify molecular mechanisms involved in rice adaptation to p deficiency, we applied a proteomic approach to compare a rice parental line, nipponbare (sensitive), and its near isogenic line (nil6-4) (resistant). the experiment was conducted using a completely randomized ...

background: viscerotropic leishmaniasis caused by leishmania tropica poses a significant prob­lem in the diagnosis and treatment management. since differential gene expression is more im­portant in outcome of the infection, we employed proteomic approach to identify potential pro­teins involved in visceralization of l. tropica . methods: the proteomes profiling of l. tropica isolated from cutan...

tau is one of several types of microtubule-associated proteins (maps), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses, abe...

background: saccharomyces boulardii (s. boulardii) is the best known probiotic yeast. the genetic engineering of this probiotic strain requires the availability of appropriate mutants to accept various gene constructs carrying different selection markers. as the auxotrophy selection markers are under focus, we have generated a ura3 auxotroph mutant of s. boulardii for use in further genetic man...