BACKGROUND To analyze trends in LBW (low birth weight) rate using birth registry data and identify factors associated with LBW in São Luís comparing two birth cohorts separated by a 12-year interval. METHODS 2,426 births were included in 1997/98 and 5,040 in 2010. The dependent variable was LBW (<2,500 g). Multiple logistic regression was performed to determine the association of independent ...

OBJECTIVE To describe changes in prescription of hormone replacement therapy (HRT) in Asturias (Spain) after the publication of the results of the Women's Health Initiative and the Million Women Study and following the recommendations of the Spanish Drugs Agency to women and prescribers (2004-2005). METHODS We performed a quasiexperimental study with no control group. The data used consisted ...

In the SIOP Wilms' tumor (WT) studies, preoperative chemotherapy is used as primary treatment, and tumors are classified thereafter by pathologists. Completely necrotic WTs (CN-WTs) low-risk tumors. The aim of study was to evaluate whether a subset regressive type (RT-WTs) (67%-99% chemotherapy-induced changes [CIC]) showing an exceptionally good response had comparably excellent survivals CN-W...

OBJECTIVE To estimate time trends in the recourse to radical prostatectomy (RP) and associated short-term outcomes after RP in Italy, as population-based data on RP adoption and outcomes are available mainly from Northern America and Northern Europe. PATIENTS AND METHODS All RPs for prostate cancer performed between 2001 and 2010 were extracted from the Italian national archive of hospital di...

HSCs are the founder cells of the adult hematopoietic system, and thus knowledge of the molecular program directing their generation during development is important for regenerative hematopoietic strategies. Runx1 is a pivotal transcription factor required for HSC generation in the vascular regions of the mouse conceptus the aorta, vitelline and umbilical arteries, yolk sac and placenta 1, 2. I...

The Atlantic Meridional Overturning Circulation (AMOC) is a key component of the climate through its transport heat in North Ocean. Decadal changes AMOC, whether internal variability or anthropogenically forced weakening, therefore have wide-ranging impacts. In this Review, we synthesize understanding contemporary decadal bringing together evidence from observations, ocean reanalyses, models an...

Outer space has been a favourite theme of science fiction literature for a long time, with Stanley Kubrick's movie, 2001: A Space Odyssey (1968) being a climax in this regard. People are also interested by inner space. In Fantastic Voyage (Richard Fleischer, 1966), miniature submarines allow a medical team to adventure into the familiar and mysterious universe of the human body. In a certain wa...