Antarctic krill embryos and larvae were experimentally exposed to 380 (control), 1000 and 2000 µatm pCO₂ in order to assess the possible impact of ocean acidification on early development of krill. No significant effects were detected on embryonic development or larval behaviour at 1000 µatm pCO₂; however, at 2000 µatm pCO₂ development was disrupted before gastrulation in 90 per cent of embryos...

Improving our ability to accurately predict individual risk for depression would have profound public health benefits. While there has been growing interest in understanding the relation between measures of positive emotion, such as well-being, and depression, it is not clear whether low well-being is an independent predictor of short term depression risk. We assessed whether low well-being is ...

This paper studies the tranformation of “predicate introduction”: replacing a complex formula in an existing logic program by a newly defined predicate. From a knowledge representation perspective, such transformations can be used to eliminate redundancy or to simplify a theory. From a more practical point of view, they can also be used to transform a theory into a normal form imposed by certai...

This paper (SPE 141950) was accepted for presentation at the SPE Reservoir Simulation Symposium, The Woodlands, Texas, USA, 21–23 February 2011, and revised for publication. Original manuscript received for review 15 December 2010. Revised manuscript received for review 12 May 2011. Paper peer approved 15 July 2011. Summary Subsurface geology is highly uncertain, and it is necessary to account ...

BACKGROUND Peramivir, an investigational intravenous neuraminidase inhibitor in Phase 3 trials for hospitalized patients, was made available during the 2009 H1N1 influenza pandemic under the Emergency Investigational New Drug (eIND) regulations. We describe the clinical characteristics and outcomes of all patients for whom peramivir was requested under the eIND. METHODS After obtaining eIND a...

A class of relational structures is said to have the extension preservation property if every first-order sentence that is preserved under extensions on the class is equivalent to an existential sentence. The class of all finite structures does not have the extension preservation property. We study the property on classes of finite structures that are better behaved. We show that the property h...

Automated patch clamping addresses the need for high-throughput screening of chemical entities that alter ion channel function. As a result, there is considerable utility in the pharmaceutical screening arena for novel platforms that can produce relevant data both rapidly and consistently. Here we present results that were obtained with an innovative microfluidic automated patch clamp system ut...

Thermally activated escape of an over-damped particle from a metastable well under the action of a time-ramped force is studied. We express the mean first passage time (MFPT) as the solution to a partial differential equation, which we solve numerically for a model case. We discuss two approximations of the MFPT, one of which works remarkably well over a wide range of loading rates, while the s...

Inverse lighting is a technique for recovering the lighting environment of a scene from a single image of an object. Conventionally, inverse lighting assumes that a pixel value is proportional to radiance value, i.e. the response function of a camera is linear. Unfortunately, however, consumer cameras usually have unknown and nonlinear response functions, and therefore conventional inverse ligh...

Screening clinics are held twice weekly, at times when all the examination rooms are available; one in the morning, the other in the afternoon. Two doctors consult at these clinics, which allows greater freedom of times, and some choice of doctor. Our own nurse attends the clinic, and the forms, partly prepared in advance, are completed by a receptionist on the patient's arrival. This helps to ...