Public transport mode share for young people appears to be growing in the 21 Century, and higher than previous mode shares appear likely to continue, increasing overall demand as today’s youths age into traditionally lower public transport-use lifecycle stages. This paper tests and supports the latter claim through application of a number of binomial logistic regression models, controlling for ...

...............................................................................................iii Acknowledgments...................................................................................iv Dedication..............................................................................................v Chapter 1 – Introduction......................................................................

Comorbid conditions play a pivotal role in rheumatoid arthritis management and outcomes. We estimated the percentage of comorbid illness among rheumatoid arthritis patients and explored the relationship between this comorbidity and different prescriptions. A cross-sectional study of patients with rheumatoid arthritis in three centers in Saudi Arabia was carried out. Comorbidity and antirheumato...

Effects of the histone deacetylase (HDAC) inhibitor MS-275 have been examined in human leukemia and lymphoma cells (U937, HL-60, K562, and Jurkat) as well as in primary acute myelogenous leukemia blasts in relation to differentiation and apoptosis. MS-275 displayed dose-dependent effects in each of the cell lines. When administered at a low concentration (e.g., 1 M), MS-275 exhibited potent ant...

Our overall objective is to translate a domain-specific document in a foreign language (in this case, Chinese) to English. Using automatically induced domain-specific, comparable documents and language-independent clustering, we apply domain-tuning techniques to a bilingual lexicon for downstream translation of the input document to English. We will describe our domain-tuning technique and demo...

Synthetic benzamide derivatives were investigated for their ability to inhibit histone deacetylase (HDA). In this study, one of the most active benzamide derivatives, MS-27-275, was examined with regard to its biological properties and antitumor efficacy. MS-27-275 inhibited partially purified human HDA and caused hyperacetylation of nuclear histones in various tumor cell lines. It behaved in a...

Adenosine monophosphate-activated protein kinase (AMPK) is a principal intracellular energy sensor which regulates energy producing pathways and energy requiring pathways when the cellular AMP/ATP ratio is altered. BML-275 (compound C), a well-known inhibitor of AMPK, has been found to induce apoptosis in myeloma, glioma and prostate cancer cells....

The present paper explores the tragic vision reflected in the poet’s relationship with the fair young man in the Fair Youth group in Shakespeare’s Sonnets. It investigates into the cult of friendship in the Renaissance, and further analyzes Shakespeare’s attitude towards the true friendship. On the basis of the poet’s artistic criteria and his purpose of living, it also examines the causes of t...