A small series of tetrahydroindazoles was prepared, starting from 2-acetylcyclohexanone and different hydrazines using reflux and a focused microwave reactor. Microwave irradiation (MW) favored the formation of the desired products with improved yields and shortened reaction times. This is a simple and green method for the synthesis of substituted tetrahydroindazole derivatives. The in vitro an...

Five new thiosulfate based inorganic-organic hybrid open-framework compounds have been synthesized employing mild reaction conditions. Of the five compounds, [Na(2)(H(2)O)(8)][Cd(C(10)H(8)N(2))(S(2)O(3))(2)].2H(2)O, I and [Cd(2)(C(10)H(8)N(2))(2)(HS(2)O(3))(2)(S(2)O(3))(2)][(C(10)H(9)N(2))(2)(C(10)H(8)N(2))(2)].8H(2)O, II have one-dimensional (1D) structures and [Cd(C(10)H(8)N(2))(H(2)O)(2)(S(2...

The Ni-catalyzed reaction of aromatic amides with alkynes in the presence of KOBu t involves C-H/N-H oxidative annulation to give 1(2H)-isoquinolinones. A key to the success of the reaction is the use of a catalytic amount of strong base, such as KOBu t . The reaction shows a high functional group compatibility. The reaction with unsymmetrical alkynes, such as 1-arylalkynes, gives the correspon...

Puerariae Flos, the flowers of Pueraria. lobata (WILLD.) OHWI, is an important oriental crude drug used to ameliorate crapulence. In the preceding paper,' we described two triterpenoidal glycosides of the sophoradiol glucuronides, along with the known six aromatic compounds, kakkalide, daidzin, genistin, rutin, robinin and nicotiflorin. This paper further deals with a tryptophan derivative, ten...

In the title compound, C(14)H(10)N(2)S(5) [systematic name; 3-({2-[4-(pyridin-4-yl)-2H-1,3-dithiol-2-yl-idene]-2H-1,3-dithiol-4-yl}sul-fan-yl)propane-nitrile], all of the non-H atoms except for the cyano-ethyl-sulfanyl group, are approximately coplanar [maxium deviation = 0.090 (3) Å]. The two five-membered 1,3-dithiole rings are twisted by 2.6 (2)°. Weak inter-molecular S⋯S inter-actions occur...

An oxidative reaction for the synthesis of 4-alkyl-substituted dihydroisoquinolin-1(2H)-ones with N-allylbenzamide derivatives as starting materials has been developed. The radical alkylarylation reaction proceeds through a sequence of alkylation and intramolecular cyclization. The substituent on the C-C double bond was found to play a key role for the progress of the reaction to give the expec...

Amination of the 2-aryl-6-bromo-4-chloro-8-iodoquinazolines with 2-aminoethanol followed by acid-promoted cyclodehydration of the incipient 2-((6,8-dihalo-2-phenylquinazolin-4-yl)amino)ethanols afforded the corresponding novel 5-aryl-9-bromo-7-iodo-2,3-dihydro-2H-imidazo[1,2-c]quinazolines. The latter were, in turn, subjected to sequential (Sonogashira and Suzuki-Miyaura) and one-pot two-step (...

3-phenylaminoisoxazol-5(2h)-ones,s ubstituted on nitrogen with an isoquinoline or quinazoline group, react with tertiary amine bases to give imidazo annelated compounds. when the n-substituent is a nitropyridine, 2-aminoindole derivatives are formed instead. evidence is presented that the reactions proceed by initial addition of the tertiary arnine to c-4