in order to investigate the effects of peppermint (mentha piperita l.) alcoholic extract on liver injury caused by the oxidant carbon tetrachloride (ccl4), an experiment was performed as a completely randomized design in a factorial arrangement (2 × 2) with 4 replications of 10 broilers each. factors included two levels of peppermint leaf alcoholic extract (0 and 2 ml/kg body weight) and ccl4 (...

AIM To investigate whether morin can reduce hepatic fibrosis by activating the NF-E2-related factor 2 (Nrf2) signaling pathway. METHODS Twenty male Sprague-Dawley rats were randomly divided into four groups: control group, morin group, carbon tetrachloride (CCl4) group, and morin + CCl4 group. Rats in both the CCl4 and morin + CCl4 groups were injected intraperitoneally with CCl4 at a dose of...

In India, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. No systemic study has been done on protective effect of Cucumis trigonus Roxb. (Cucurbitaceae) to treat hepatic diseases. Protective action of C. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...

BACKGROUND Sonchus arvesis is traditionally reported in various human ailments including hepatotoxicity in Pakistan. Presently we designed to assess the protective effects of methanolic extract of Sonchus arvesis against carbon tetrachloride induced genotoxicity and DNA oxidative damages in hepatic tissues of experimental rats. METHODS 36 male Sprague-Dawley rats were randomly divided into 6 ...

AIM To study the molecular mechanisms involved in the hepatoprotective effects of naringenin (NAR) on carbon tetrachloride (CCl4)-induced liver fibrosis. METHODS Thirty-two male Wistar rats (120-150 g) were randomly divided into four groups: (1) a control group (n = 8) that received 0.7% carboxy methyl-cellulose (NAR vehicle) 1 mL/daily p.o.; (2) a CCl4 group (n = 8) that received 400 mg of C...

Abstract: The role of intracellular Ca2+ in CCl4 hepatotoxicity in rats was clarified by measuring detailed changes in serum ALT values and intracellular Ca2+ after CCl4 administration. Intracellular Ca 2+ responded to CCl4 intoxication with a biphasic increase. The first intracellular Ca 2+ peak increased up to 5.6-fold the control level at 1 hour, and the second Ca2+ peak 6.5-fold at 3.5 days...

Abstruct: F The role of the S100A4 in rat hepatocites was clarified by measuring detailed changes in serum ALT values and intracellular Ca2+ after CCl4 administration. In this study, we further showed that the calcium binding protein S100A4 might be a protein signal involved in the response to protect cells against CCl4 intoxication. S100A4 mRNA expression levels abruptly increased to a high le...

this study aimed to evaluate the antioxidant property of chavir plant on japanese quail intoxicated with carbon tetrachloride (ccl4). eighty, one-d-old japanese quail chicks were randomly allotted to 4 treatments with 4 replicates and 5 chicks in each, using completely randomized design with 2×2 factorial arrangements including 2 levels of chavir powder (0 and 1.5 percent) and ccl4 (0 and 1 ml/...

The protective and therapeutic effects of fucoidan extract from Laminaria species against liver damage induced by CCl4 in rats was investigated by monitoring the serum level and hepatic m-RNA expression of TGFβ-1, liver and renal markers, as well as oxidative stress and antioxidant biomarker. Thirty six adult male albino rats were divided into 4 equal groups; one was used as a negative control ...

BACKGROUND Ginsenosides, the major bioactive compounds in ginseng root, have been found to have antioxidant, immunomodulatory and anti-inflammatory activities. This study investigated the effects of ginsenosides on carbon tetrachloride (CCl4)-induced hepatitis and liver fibrosis in rats. METHODS Male Sprague-Dawley rats were randomly divided into four groups: control, CCl4, CCl4 + 0.5 g/kg Pa...