in this work we synthesized nano hydroxyapatite (hap)  by sol-gel method, then we functionalized hydroxyapatite nanoparticle by use of  3-aminopropyl trimethoxysilane (aptms) , to improve the loading and control release of sulfasalazine drug bonded to aptms. the drug release patterns from sulfasalazine loaded hap nanoparticles at ph value 8 for 6h, sulfasalazine loaded functionalized hap nanopa...

An alternative strategy for the synthesis of 1-aryl- and 1-alkyl-2-methylsulfanyl-4-(4-fluorophenyl)-5-(pyridin-4-yl)imidazoles as potential p38α mitogen-activated protein kinase inhibitors is reported. The regioselective N-substitution of the imidazole ring was achieved by treatment of α-aminoketones with different aryl or alkyl isothiocyanates. In contrast to previously published synthesis ro...

A general approach for the synthesis of bis(imidazolium) dichloride salts from imidazoles and dichloroalkanes is reported. Typical limitations this reaction formation methylene-bridge...

in this research, (carboxy-3-oxopropylamino)-3-propylsilylcellulose (copapsc) as an organocatalyst, has been synthesized by grafting of succinic anhydride on the nh2-modified cellulose (cellulose functionalized with 3- aminopropyltriethoxysilane). the –co2h group-functionalized cellulose (copapsc) is used as a catalyst for the synthesis of coumarin derivatives from the reaction of phenolic subs...

starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. from the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as prepared. reaction of compound 15 with diazomethane gave i-methyl-2-(3-pyridy1)-5- nitroimidazol(e7 ) in addition to 6. the antibacterial and antif...

Substituted imidazoles and oxazoles were respectively hydrogenated into the corresponding chiral imidazolines and oxazolines (up to 99% ee). The highly enantioselective hydrogenation was achieved by using the chiral ruthenium catalyst, which is generated from Ru(η(3)-methallyl)(2)(cod) and a trans-chelating chiral bisphosphine ligand, PhTRAP. This is the first successful catalytic asymmetric re...

The three imidazole antimycotics clotrimazole, miconazole, and ketoconazole all inhibit the demethylation of lanosterol to ergosterol, resulting in inhibition of growth of Saccharomyces cerevisiae; this is a fungistatic action. At higher concentrations clotrimazole and miconazole are fungicidal, whereas ketoconazole is not. The fungicidal action reflects direct membrane damage by the imidazoles...

A short and efficient synthesis of 1,4-disubstituted imidazoles has been developed which provides the desired products with complete regioselectivity. This protocol allows preparation of compounds which are challenging to prepare by current literature methods in a regioselective fashion, a sterically and electronically diverse range of N-substituents being accessible. The sequence involves an u...