We studied the effect of pH on ligand binding in wild-type lactose permease or mutants in the four residues-Glu-269, Arg-302, His-322, and Glu-325-that are the key participants in H(+) translocation and coupling between sugar and H(+) translocation. Although wild-type permease or mutants in Glu-325 and Arg-302 exhibit marked decreases in affinity at alkaline pH, mutants in either His-322 or Glu...

Analysis of V3 and C4 sequences of HIV-1 reveals correlated mutations at gp120 positions 322 and 440, and a very strong preference for a positively charged residue at position 440 when position 322 is negatively charged. This observation suggests that these two residues are close to each other and interact electrostatically in R5 viruses. This interaction was used to model V3 in the context of ...

INTRODUCTION .......................................... 319 METHODS TO ESTIMATE BENEFITS ........................... 320 ESTIMATING THE BENEFITS OF ABATEMENT USING THE DIRECT METHOD ........................................ 322 Local or National Estimates? ................................. 322 Estimating the Health Effects of Air Pollution ...................... 323 Estimation of the Marginal Be...

Dept. of Pathology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Corresponding author and reprints: Shahriar Dabiri MD FIAC, Pathology Department, Afzalipour Hospital, Kerman University of Medical Sciences, 22 Bahman Blvd., Kerman, Iran. Tel: +98-341-322-2250-60, Fax: +98-341-322-2763, E-mail: [email protected]. Received: 2015 Mar 22 Accepted: 2016 Apr 07 ...

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The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). UPR can facilitate the restoration of cellular homeostasis, via the concerted activation of three ER stress sensors, namely IRE1, PERK and ATF6. Global approaches in several cellular contexts have revealed that UPR regulates the expression of many miRNAs tha...

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INTRODUCTION Keratoacanthoma is a fast-growing crateriform skin tumor. Approximately 25% of such tumors undergo malignant transformation and develop areas of squamous cell carcinoma (SCC). The presence of laminin-322 has been associated with progression to invasive forms of SCC. The aim of this study was to determine whether or not immunohistochemical staining for laminin-322 would be of value ...

OBJECTIVES New antimicrobials are essential to prevent gonorrhoea becoming an untreatable infection. Herein, the in vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against Neisseria gonorrhoeae strains were investigated and compared with antimicrobials currently or previously recommended for treatment of gonorrhoea. METHODS MICs (mg/L) were ...