We have demonstrated that the isoflavone, genistein, stimulates growth of estrogen-dependent human breast cancer (MCF-7) cells in vivo (C. Y. Hsieh et al., Cancer Res., 58: 3833-3838, 1998). The isoflavones are a group of phytoestrogens that are present in high concentrations in soy. Whether consumption of genistein from soy protein will have similar effects on estrogen-dependent tumor growth a...

AIM To analyze mortality associated with hepatitis C virus (HCV) and hepatitis B virus (HBV) infection in Italy. METHODS Death certificates mentioning either HBV or HCV infection were retrieved from the Italian National Cause of Death Register for the years 2011-2013. Mortality rates and proportional mortality (percentage of deaths with mention of HCV/HBV among all registered deaths) were com...

CONTEXT Right heart catheterization (RHC) is commonly performed before high-risk noncardiac surgery, but the benefit of this strategy remains unproven. OBJECTIVE To evaluate the relationship between use of perioperative RHC and postoperative cardiac complication rates in patients undergoing major noncardiac surgery. DESIGN Prospective, observational cohort study. SETTING Tertiary care tea...

The aim of this paper is twofold: first, we strive to find routes flint supply that may have been used systematically on the northern Alpine Foreland during fourth millennium BCE, based origin siliceous raw materials; second, these will be interpreted as a part cultural entanglements. Using sedimentary microfacies method for sourcing materials artefacts recovered in prehistoric sites makes it p...

Abstract Background tRNA-derived fragments (tRFs) are 14–40-nucleotide-long, small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions in many biological processes. Many studies have shown that tRFs associated Argonaute (AGO) complexes and inhibit gene expression the same manner as miRNAs. However, there currently no tools for accurately predicting tRF targe...

Purpose Current prediction models for advanced age-related macular degeneration (AMD) are based on a restrictive set of risk factors. The objective this study was to develop comprehensive model applying machine learning algorithm allowing selection the most predictive factors automatically. Design Two population-based cohort studies. Participants Rotterdam Study I (RS-I; training set) included ...

Abstract. Regional monitoring of rock slope failures using the seismic technique is rarely undertaken due to significant source location errors; this method also still lacks signal features needed understand events type because complex mass movement involved. To better comprehend these types events, 10 known along highways in Taiwan were analyzed. First, a hybrid (GeoLoc) composed cross-correla...

Abstract Background The prevalence of coronary artery disease (CAD) in patients with severe aortic valve stenosis undergoing transcatheter implantation (TAVI) is high. However, the importance a percutaneous intervention (PCI) prior to TAVI has been matter debate. Importantly, are characterized by high age often accompanied highly calcified arteries, increasing risk periprocedural complications....

BACKGROUND Barium enema (BE) is widely available for diagnosis of colorectal cancer despite concerns about its accuracy and acceptability. Computed tomographic colonography (CTC) might be a more sensitive and acceptable alternative. We aimed to compare CTC and BE for diagnosis of colorectal cancer or large polyps in symptomatic patients in clinical practice. METHODS This pragmatic multicentre...