Introduction: The antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. One of the major components of this pathway is the nucleus raphe magnus (NRM). Our previous study demonstrated the involvement of NRM in the analgesic effect of morphine microinjected into the nucleus cuneiformis (NCF) in a descending manner. The aim of the current study...

OBJECTIVE: Social belief and experimental evidences indicate that opium and its alkaloids, morphine, produced hypoglycemic effects in animal models. This study was conducted in order to determine the role of morphine on blood glucose and insulin. MATERIAL AND METHODS: This is an empirical analysis investigating the laboratory albino male rats weighing 200-250 g. Rats in the control group recei...

Drug addiction has developed to a social illness. Changes in glutamate transmission have been recorded by the repeated administration of addictive drugs into VTA. In this investigation, In vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (VTA) in freely moving rats. Rats were anesthetized with chloral hydrate (350 mg/kg, i.p.) and...

objective: we aimed to evaluate the efficacy of celecoxib in reducing intrathecal morphine-induced pruritus in parturient undergoing cesarean section delivery under spinal anesthesia. materials and methods: in a randomized double-blind placebo controlled study 126 women undergoing elective cesarean section under spinal anesthesia (0.5% bupivacaine 12mg plus 0.2 mg preservativefree morphine )wer...

introduction: the role of midbrain reticular formation, which includes the nucleus cuneiformis (ncf), as a crucial antinociceptive region in descending pain modulation has long been investigated. in this study, we tried to highlight the role of ncf in morphine-induced antinociception in formalin-induced pain model in rats. methods: a total of 201 male wistar rats weighing 260-310 g were used in...

opiates such as morphine are one of the most effective classes of medication prescribed to treat both acute and chronic pain.they act to suppress pain through mu-receptor activation on primary afferent nerve fibers, dorsal horn neurons and supraspinal pain center neorons. when morphine is administered epidurally, it diffuses to the cord substance, producing analgesia [1],the aim of this study w...

introduction: the antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. one of the major components of this pathway is the nucleus raphe magnus (nrm). our previous study demonstrated the involvement of nrm in the analgesic effect of morphine microinjected into the nucleus cuneiformis (ncf) in a descending manner. the aim of the current study wa...

Calcium, through its various channels involves in local, spinal and supra-spinal transmission of pain. In the present study, we investigated the separate and combined treatment effects of verapamil (a calcium channel blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) on pain in the orofacial region of rats. Orofacial pain was induced by subcutaneous (SC) injection of for...

this study investigated efficacy and side effects of morphine suppository for pain management after the first elective caesarean delivery in comparison to diclofenac suppository. one hundred women aged 18-40 with term pregnancies undergoing elective caesarean section for the first time participated in this prospective project. exclusion criteria included drug sensitivity, fetal malformations or...