Colorectal cancer is one of the most common malignancies, which has seriously affected people's health. Abnormal expression of long non-coding RNAs and microRNAs are closely related to the process of occurrence, development, invasion and metastasis of colorectal cancer. However, the effect of lnc CCAT1 on human HCT-116/HCT-8 cells and its potential mechanism were investigated. In present study,...

fecundity is one of the important indicators of reproduction biology in fishes especially in rearing and restocking management of endangered species such as sturgeon. the fecundity of stellate sturgeon (acipenser stellatus pallas, 1771) was studied in 50 specimens captured by gill net (mesh size= 100 mm) and seine net in different fishing areas along the southeastern part of the caspian sea fro...

the effect of chloride ions concentration on the electrochemical behavior of aisi 410 stainless steel in thesimulated concrete pore (0.1 m naoh + 0.1 m koh) solution was investigated by various electrochemicalmethods such as potentiodynamic polarization, mott–schottky analysis and electrochemical impedancespectroscopy (eis). potentiodynamic polarization curves revealed that increasing chloride ...

BACKGROUND Chondrogenic differentiation of mesenchymal stem cells (MSCs) is important for osteoarthritis (OA) treatment. However, the specific mechanisms involved are undefined. MicroRNAs (miRNAs) downregulate protein synthesis by binding to the 3'UTR of target mRNA. METHODS Bone marrow aspirates were obtained from OA patients undergoing total hip arthroplasty (n=8) to isolate MSCs. MiR-410 o...

Stellate sturgeon (Acipenser stellatus) is a species of great conservation concern throughout its range. Over the past century, it has experienced dramatic decline in abundance and distribution Black Sea basin. Information regarding genetic structure very limited region, despite crucial importance for developing adequate management plans species’ recovery. Samples from 163 A. stellatus were ana...

[1] Receiver functions recorded by the 54‐station 920 km long Program for Array Seismic Studies of the Continental Lithosphere–Incorporated Research Institutions for Seismology Colorado Plateau/Rio Grande Rift Seismic Transect Experiment (LA RISTRA) line array display a pervasive negative polarity P to S conversion (Pds) arrival preceding the positive polarity 410 km discontinuity arrival. Thes...

Asteltoxins belong to a group of polyene pyrone mycotoxins that are known be potent inhibitors mitochondrial ATP synthesis and hydrolysis. Asteltoxin A was first isolated from the toxic maize cultures Aspergillus stellatus. Several attempts have been made synthesize asteltoxin A, starting with bis(tetrahydrofuran) moiety has demonstrated previously in biosynthetic studies. This review highlight...

[1] Teleseismic receiver function analysis of data from six dense arrays in the western U.S. is used to inves­ tigate mantle transition zone (MTZ) discontinuities and the prevalence of a low‐velocity layer atop the 410 km discontinuity (410‐LVL). Negative polarity Ps arrivals indicative of a low‐velocity layer with a top 25–60 km above the 410 are identified in 8–11 out of 18 stacks of receiver...

Calpains are calcium-dependent enzymes that determine the fate of proteins through regulated proteolytic activity. Calpains have been linked to the modulation of memory and are key to the pathogenesis of Alzheimer disease (AD). When abnormally activated, calpains can also initiate degradation of proteins essential for neuronal survival. Here we show that calpain inhibition through E64, a cystei...