Snake venoms affect blood coagulation and platelet function in a complex manner. However, two classes of venom proteins, snaclecs and disintegrins have been shown to specifically target receptors including GPIb, α2β1, GPVI, CLEC-2 and integrins αIIbβ3, αvβ3, α5β1 expressed on platelets, endothelial cells, phagocytes, tumor cells, thus affecting cell-matrices and cell-cell interactions. Here, we...

The hydrothermal reaction of cobalt(II) nitrate hexahydrate with 5-(benzimidazol-1ylmethyl)isophthalic acid (H2L) leads to the formation of a complex [Co(L)] (1). In the presence of 2-(pyridin-2-yl)-1H-benzimidazole (pybim) as an auxiliary ligand, a complex [Co(L)(pybim)]·H2O (2) was obtained. The complexes 1 and 2 have been characterized by single-crystal and powder X-ray diffraction, IR spect...

This study explores various barriers to managing Blood Sugar Levels (KGD) in type 2 DM patients. The method used is a systematic review by browsing articles the ScienceDirect, Ebsco, PubMed, CINAHL and PMC databases selected based on PRISMA diagram. results showed that some blood sugar management were related limited costs, poor medication adherence, common knowledge of diabetes, patient psycho...

We have measured the Pancharatman phase difference between electrical field emerging from conical diffraction (CD) phenomenon in KGd(WO2)4 (KGW) biaxial crystal and a vertical polarized reference, each traveling one arm of an interferentiel conoscope. This is obtained as retardation introduced by liquid retarder reference beam which maximizes interference intensity for camera pixel. The full ch...

The potassium double tungstates KGd(WO4)2, KY(WO4)2, and KLu(WO4)2 are excellent candidates for solid-state lasers, see Ref. [1] and Refs. therein, because of their high refractive index of ~2.02.1, the large transition cross-sections of rare-earth (RE) ions doped into these hosts, the possibility to incorporate very large concentrations of RE 3+ ions, reaching the stoichiometric structure KRE(...

Laminated paperboard is used as a packaging material for a wide range of products. During production of the packaging, the fold lines are first defined in a so-called creasing (or scoring) operation in order to obtain uncracked folds. During creasing as well as folding, cracking of the board is to be avoided. A mechanical model for a single fold line has been proposed in a previous study (Beex ...

Before the introduction of routine measurements of serum calcium in ambulatory services, PHTP (primary hyperparathyroidism) was symptomatic with classic bone disease (known as osteitis fibrosa cystica) nephrolithiasis, and acute neuropsychiatric syndrome with severe hypercalcemia. Currently, PHPT presents few unspecific symptoms. This cross-sectional study was conducted from December 1, 2007, t...