Mixture models have been widely used for data clustering. However, commonly used mixture models are generally of a parametric form (e.g., mixture of Gaussian distributions or GMM), which significantly limits their capacity in fitting diverse multidimensional data distributions encountered in practice. We propose a non-parametric mixture model (NMM) for data clustering in order to detect cluster...

Abstract Neural mass models are among the most popular mathematical of brain activity, since they enable rapid simulation large-scale networks involving different neural types at a spatial scale compatible with electrophysiological experiments (e.g. local field potentials). However, establishing model (NMM) equations associated specific neuronal network architectures can be tedious and is an er...

Abstract Sensitive quantification of microRNA (miRNA) plays a crucial role in early diagnosis and precise therapy osteosarcoma. Herein, we build label-free sensitive miRNA approach based on the activation split-DNAzyme initiated primer exchange reaction (PER). Target cooperates with Mg 2+ through assisting assembly DNAzyme to correct conformation, which enables performance PER-based nucleic aci...

We revisit the problem of (1±ε)-approximating the Lp norm, 0 ≤ p ≤ 2, of an n-dimensional vector updated in a stream of length m with positive and negative updates to its coordinates. We give several new upper and lower bounds, some of which are optimal. LOWER BOUNDS.We show that for the interesting range of parameters, Ω(ε log(nm)) bits of space are necessary for estimating Lp in one pass for ...

Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPC1 at 1q24-q25 (OMIM #601518) and HPCX at Xq27-q28 (OMIM #300147). Genetically homogeneous populations, such as that of Finland, and distinct subsets of families may help to minimize the genetic heterogeneity that complicates the genetic dissection of complex traits. Here, the role of the HPC1, and...

The aim of this study was to assess the effect of bracket type on the labiopalatal moments generated by lingual and conventional brackets. Incognito™ lingual brackets (3M Unitek), STb™ lingual brackets (Light Lingual System; ORMCO), In-Ovation L lingual brackets (DENTSPLY GAC), and conventional 0.018 inch slot brackets (Gemini; 3M Unitek) were bonded on identical maxillary acrylic resin models ...

Genome-wide association studies (GWAS) of 10 different cancers have identified pleiotropic cancer predisposition loci across a region of chromosome 5p15.33 that includes the TERT and CLPTM1L genes. Of these, susceptibility alleles for pancreatic cancer havemapped to theCLPTM1L gene, thus prompting an investigation of the function of CLPTM1L in the pancreas. Immunofluorescence analysis indicated...

Genome-wide association studies (GWAS) of 10 different cancers have identified pleiotropic cancer predisposition loci across a region of chromosome 5p15.33 that includes the TERT and CLPTM1L genes. Of these, susceptibility alleles for pancreatic cancer have mapped to the CLPTM1L gene, thus prompting an investigation of the function of CLPTM1L in the pancreas. Immunofluorescence analysis indicat...

Aim—To detect specific tumour infiltrating T cells (TIL) carrying antigen specific MHC-I restricted receptor genes on necrotising and non-necrotising malignant melanomas and to correlate the findings with clinical data. Methods—á/â− and ã/ä− TIL were determined by immunohistochemical staining in melanomas of patients with known follow up of more than 10 years. An antigen retrieval method was us...

As a kind of tiny gear based on space curve meshing theory, the line is very suitable for miniaturized machines due to its compact size and low weight. However, usually suffers from serious vibration problems since teeth are designed as twisted three-dimensional cantilevers provide conjugated curves. A dynamic model pair established in this paper using numerical manifold method (NMM) alleviate ...