Immune tolerance to self-antigens is established during lymphocyte differentiation in the thymus, but a simple means to induce antigen-specific tolerance in the thymus is still elusive. We show here that intrathymic injection of a lentiviral vector expressing the hemagglutinin antigen (HA) in TCR-HA transgenic mice resulted in negative selection of HA-specific effector T cells and sustained pos...

BACKGROUND Hyaluronan (HA) is a connective tissue component with unique water binding and pro-inflammatory properties. It has been suggested that HA is involved in normal renal water handling but also in several pathological conditions such as organ rejection and ischaemia-reperfusion (IR) injury. METHODS In anaesthetized normal rats we investigated if renal cortical HA accumulation and the i...

Since HA-1-specific T cells have been shown to make a significant contribution to the clinical responses in patients with relapsed leukemia, we investigated the feasibility of adoptive transfer of in vitro induced HA-1-specific CD8 positive T cells to patients with relapsed leukemia after allogeneic stem cell transplantation. The in vitro generation of clinical grade HA-1-specific T-cell lines ...

A field experiment was conducted during the winter (rabi) seasons of 2017–18 and 2018–19 at Rajasthan College Agriculture, Maharana Pratap University Agriculture Technology, Udaipur, Rajasthan, to find out best integrated nutrient management strategy in barley (Hordeum vulgare L.). The correlation regression were studied between yield attributes as influenced by these treatments. laid a randomi...

Targeting of antigens to immature dendritic cells has been shown to result in antigen-specific T-cell tolerance in vivo. In the INS-HA/TCR-HA transgenic mouse model for type 1 diabetes, we tested the potential of the dendritic cell-specific monoclonal antibody DEC-205 conjugated to the hemagglutinin (HA) antigen (DEC-HA) to prevent disease onset. Whereas untreated INS-HA/TCR-HA mice all develop...

Carbon dioxide is an important greenhouse gas and a major agent of climate change. This study quantified carbon (C) emissions from energy consumption and C storage and uptake by greenspace for three cities in middle Korea: Chuncheon, Kangleung, and Seoul. Carbon emissions were estimated using C emission coefficients for fossil fuels consumed. Carbon storage and uptake by woody plants were compu...

An experiment was conducted during the rainy (kharif) season of 2018 and 2019 at research farm College Agriculture Tripura, Lembucherra, West to identify a viable agro-technique for improving productivity medium-duration pigeonpea [Cajanus cajan (L.) Millsp]. Treatments comprised all possible combination no nipping (N0 ), @ 45 days after sowing (DAS) (N45), 60 DAS (N60) 90 (N90) with row-to-row...

A hallmark of the immune response to influenza is repeated encounters with proteins containing both genetically conserved and variable components. Therefore, the B and T cell repertoire is continually being remodeled, with competition between memory and naïve lymphocytes. Our previous work using a mouse model of secondary heterosubtypic influenza infection has shown that this competition result...

filed experiment was conducted to study the effect of manure and various combinations of foxtail millet and mungbean intercropping on the grain yield, weed performance,and the nutrients concentration in millet. the experimental design was a split plot with three replications. main plots were differentmanure rates (0, 15 and 30 t ha-1) and the subplots comprised five combinations of intercroppin...

This study was carried out in 2004 in Iguacu National Park (INP), Paraná-Brazil. The vegetation is composed of Araucaria Forest (AF) (13.1%) and Seasonal Semi-deciduous Forest (FES) (86.9%). Two types of materials were analyzed: litter (L) and woody material (W) (alive (A) and dead (D)), and classified by diameter: W1(0–0.70 cm), W2(0.71–2.5 cm), W3(2.51–7.50 cm), and W4(≥7.5 cm). The results f...