Based on the new findings in a recent experimental study (Lee et al., Nature 467, 82-86, 2010) that antibiotic resistant mutants of bacteria produce indoles to protect the wild strain bacteria, we propose a mathematical model to describe the evolution of the wild strain, resistant strain and indoles with limited nutrient. We distinguish two cases: (i) mutation is negligible and a resistant stra...

When is Dementia Presenile? J. A. Snowdon, M.R.A.C.P.; P. K. Bridges, M.D., D.P.M ............................. 465 Research in Psychiatry C. P. B. Brook, D.P.M.; A. Tarnopolsky, M.D. 465 Speaking Valve for Alttachment to a Tracheostomy Tube F. M. Emery, F.F.A. R.C.S ................. 466 Effect of Intravenous Infusion of Acetylsalicylic Acid on Renal Function M. Robert, and others ...............

We report on the construction of a full-length cDNA clone, pBRM33, derived from wild-type rubella virus M33 strain. The RNA transcripts synthesized in vitro from pBRM33 are highly infectious, and the viruses produced retain the phenotypic characteristics of the parental M33 virus in growth rate and plaque size. This cDNA clone was used to study the role of E1 transmembrane and cytoplasmic domai...

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