نتایج جستجو برای: 5 and 5
تعداد نتایج: 17026982 فیلتر نتایج به سال:
Serotonin (5-HT) is one of the major monoamines in the brain. It is also found in the retina, a part of the brain, where a subgroup of amacrine cells are considered to be the sole retinal source of 5-HT. The data, obtained so far, about the serotonin receptors’ function are contradictory. Therefore, our aim was to study the distribution of the 5-HT synthesizing neurons and the serotonin recepto...
A lo largo de la historia diferentes pandemias han asolado a humanidad. De todas ellas, salvo Covid-19, pues aún no ha habido tiempo llevarla gran pantalla, numerosas representaciones en el cine comercial, algunas muy relevantes desde punto vista calidad cinematográfica y científica con que están documentados los guiones. Sería inalcanzable enumerar cada una ellas. Por tanto, este artículo se p...
Molecular determinants of FlA1 fluorinase specificity were probed using 5'-chloro-5'-deoxyadenosine (5'-ClDA) analogs as substrates and FlA1 active site mutants. Modifications at F213 or A279 residues are beneficial towards these modified substrates, including 5'-chloro-5'-deoxy-2-ethynyladenosine, ClDEA (>10-fold activity improvement), and conferred novel activity towards substrates not readil...
5-hydroxymethylcytosine (5 hmC), the oxidized form of 5-methylcytosine (5 mC), is a base modification with emerging importance in biology and disease. However, like most epigenetic elements, it is transparent to many conventional genetic techniques and is thus challenging to probe. Here, we report a rapid solid-state nanopore assay that is capable of resolving 5 hmC with high specificity and se...
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