Although 5-fluorouracil induces relatively minimal thrombocytopenia in mice compared with antiplatelet serum, the ensuing rebound thrombocytosis is much greater. It also occurs several days later. Administration of 5-fluorouracil 24 hr after antiplatelet serum suppresses the increase in platelets produced by antiplatelet serum while the subsequent thrombocytosis is indistinguishable from that p...

Advanced cancer responds clinically to combined therapy with recom binant interferon-a and 5-fluorouracil. Although the two agents may interact in the biosynthetic pathway for thymidine, we investigated, as an alternative mechanism, the regulation of susceptibility of the A375 human melanoma to natural killers activated by Interferon. A375 were preincubated with 5-fluorouracil, Interferon, or b...

Bortezomib is a highly selective and reversible inhibitor of the 26S proteasome. It has been approved for the treatment of patients with relapsed and refractory multiple myeloma. A number of studies have been conducted to evaluate the activity and safety of bortezomib either alone or in combination with several cytotoxic agents and radiation. In the current study, the efficacy of bortezomib alo...

Background: Common wart is one of the most prevalent skin diseases, caused by human papilloma virus. Numerous therapeutic modalities have been used in the treatment of warts. Objectives: This study was designed to evaluate and compare the efficacy of 5% 5-fluorouracil (5-FU) ointment with cryotherapy in the treatment of common warts of hands. Patients and Methods: In a single blind, prosp...