prenatal stress in rats results in structural, physiological and behavioral alterations that persist in adulthood. serotonin (5-ht) is an important neurotransmitter known to be involved in these prenatal stress-induced behavioral alterations. the aim of the study was to investigate the effects of interrupted synthesis of 5-ht and immobilization stress during different gestational period on brai...

Decreased serotonin (5-HT) has long been linked to increased aggressive behavior. Tryptophan Hydroxylase (TPH) is an enzyme involved in the 5-HT synthesis, and para- chlorophenyl alanine (pCPA) inhibits its activity. TPH2 mRNA expression presence mainly described raphe complex rodent’s brain. 5-HT-producing neurons project their axons olfactory bulb, considered a relevant structure rodents for ...

We hypothesize that sleep state-dependent withdrawal of serotonin (5-hydroxytryptamine, 5-HT) at upper airway (UAW) dilator motoneurons contributes significantly to sleep-related suppression of dilator muscle activity in obstructive sleep apnea. Identification of 5-HT receptor subtypes involved in postsynaptic facilitation of UAW motoneuron activity may provide pharmacotherapies for this preval...

Microdialysis was used to measure the effect of benzodiazepines (BDZs) on basal levels and on stress-induced increases of 5 -hydroxytryptamine (5 -HT), 5 - hydroxyind oleacetic acid (5 -HIAA) , noradrenaline (NA), and dihydroxyphenylacetic acid (DOP AC). The stressors used were a 5 min tail pinch or a 10 min period of restraint. A subcutaneous injection of 5 mg/kg diazepam decreased basal ...

The serotonin (5-HT) syndrome occurs in humans after antidepressant overdose or combination of drugs inducing a massive increase in extracellular 5-HT. Several 5-HT receptors are known to participate in this syndrome in humans and animal models. The 5-HT(2B) receptor has been proposed as a positive modulator of serotonergic activity, but whether it is involved in 5-HT syndrome has not yet been ...

Prenatal stress in rats results in structural, physiological and behavioral alterations that persist in adulthood. Serotonin (5-HT) is an important neurotransmitter known to be involved in these prenatal stress-induced behavioral alterations. The aim of the study was to investigate the effects of interrupted synthesis of 5-HT and immobilization stress during different gestational period on brai...

microdialysis was used to measure the effect of benzodiazepines (bdzs) on basal levels and on stress-induced increases of 5 -hydroxytryptamine (5 -ht), 5 - hydroxyind oleacetic acid (5 -hiaa) , noradrenaline (na), and dihydroxyphenylacetic acid (dop ac). the stressors used were a 5 min tail pinch or a 10 min period of restraint. a subcutaneous injection of 5 mg/kg diazepam decreased basal level...

While the role of 5-hydroxytryptamine (5-HT, serotonin) in the nociceptive processing has been widely investigated in the central nervous system, information regarding its role in peripheral tissues is still lacking. Noteworthy, 5-HT induces phenotypic changes of nociceptors and peripheral injection induces pain in humans and nociceptive response in rodents. However, local receptors involved in...

The roles of 5-HT3 and 5-HT4 receptors in the modulation of intestinal propulsion by luminal application of 5-HT and augmentation of endogenous 5-HT effects were studied in segments of guinea-pig ileum in vitro. Persistent propulsive contractions evoked by saline distension were examined using a modified Trendelenburg method. When 5-HT (30 nM), fluoxetine (selective serotonin reuptake inhibitor...