Aims: The present work aimed to evaluate the anti-amoebic, antibacterial, and anti-inflammatory potential of three natural polyketides from Phomopsis sp. CAM212.
 Study Design: Clinical isolates E.histolytica, E.coli ATCC25922 strain, primary peritoneal mouse macrophages were used.
 Places Duration Study: Laboratory Pharmacology Toxicology, Medical Microbiology, Faculty Science, Unive...

Strain UHM-5, a pSym Exo derivative of the aluminum-tolerant Rhizobium leguminosarum bv. phaseoli strain CIAT899, was equally tolerant of aluminum (Al) as the parental culture. Dialyzed culture supernatants of the wild-type cells grown in YEM broth (10 cells ml) contained 185 mug of glucose equivalents ml whereas UHM-5 culture supernatants yielded 2 mug of glucose ml. The Exo derivative and the...

A derivative of quinolinecarboxylic acid, ciprofloxacin (BAY o 9867) was found to be an effective bactericidal agent against Pseudomonas aeruginosa and Escherichia coli. A bactericidal effect was achieved immediately after the addition of ciprofloxacin. At a concentration of 0.5 micrograms/ml, culture viability was reduced from 5 X 10(5) to about 5 X 10(3) CFU/ml within 15 min, and at 0.1 micro...

Neural stem cells (NSCs) as a heterogeneous multipotent and self- renewal population are found in different areas in the developing mammalian nervous system, as well as the sub-ventricular zone (SVZ) and the hippocampus of the adult brain. NSCs can give rise to neurons, astrocytes and oligodendrocytes. The aim of this study was to differentiate neural stem cells into noradrenergic-like cells in...

In the course of screening microbial fermentations for potential pharmaceutical activity, the extract from an unidentified fungus (Schering culture number SCF1082A) was found to inhibit Candida albicans. Various media and fermentation conditions were examined in an effort to maximize production of the antifungal agent. The conditions which proved to be the most productive are as follows. Stock ...

Background: This study was done to determine the effect of root extract of Acalypha indica Linn (akar kucing) in protecting neuron viability of the rat hippocampus on tissue culture in hypoxic condition. Methods: This is an experimental study of in vitro primary cell culture of hippocampus of Sprague Dowley adult rat. The cultures were group into control (C) and exposure to root extract of Acal...

5-Azacytidine (1 to 5 jug/ml) significantly inhibited mitosis of L1210 cells in culture only after 2 hr of incubation. The inhibition of mitosis was correlated to the inhibition of DNA synthesis. With asynchronous DON and LI210 cells, the cell-kill (inhibition of proliferative capacity) reached a saturation value at high doses of the drug. Any further increase in drug concentration did not resu...

5-Azacytidine (1 to 5 jug/ml) significantly inhibited mitosis of L1210 cells in culture only after 2 hr of incubation. The inhibition of mitosis was correlated to the inhibition of DNA synthesis. With asynchronous DON and LI210 cells, the cell-kill (inhibition of proliferative capacity) reached a saturation value at high doses of the drug. Any further increase in drug concentration did not resu...