BACKGROUND Isoxazoles exhibit interesting biological activities, and the 1,3-dipolar cycloaddition(13DC) reactions play an important role in both mechanistic and synthetic organic chemistry. Pyrazoles and annulated pyrazoles exhibit some diverse biological activities. They are used as antipyretic, analgesic drugs, tranquilizing, and herbicidal agents. Pyrazoles are also used extensively as usef...

Abstract A detailed study of the ability pyridine-2,6-dicarboxylic acid (1) and its 4-mono- 3,4,5-tri-substituted analogues to sensitize emission from Pr3+, Nd3+, Gd3+, Dy3+ Er3+ is presented. Sensitization Ln3+ was demonstrated via ligands in all complexes, excluding with covering spectral range 500 nm 1850 nm obtained variation ion. From ligand-based photoluminescence Gd3+-complexes, relative...

The development of multicomponent reactions for indole synthesis is demanding and has hardly been explored. The present study describes the development of a novel multicomponent, cascade approach for indole synthesis. Various substituted indole derivatives were obtained from simple reagents, such as unfunctionalized alkenes, diazonium salts, and sodium triflinate, by using an established straig...

Abstract: Background: Biocatalysis in organic solvents has several benefits over aqueous solvents, including solubility of substrates, ease workup, separation the product, and, certain cases, reusability biocatalysts. Materials and Methods: A simple, effective, environmentally friendly technique for synthesizing pyrazoles been established, which involves cyclo condensation chalcones isonicotini...

A highly selective and efficient method for the synthesis of 5-trifluoromethylated and 5-perfluoroalkylated pyrazoles has been developed which relies on the cyclization of hydrazine dianions with ethyl perfluorocarboxylates. The pyrazoles prepared were evaluated as potential inhibitors of alkaline phosphatases, namely human tissue non-specific alkaline phosphatase (h-TNAP) and tissue specific i...

The C-6 substituted tryptophan di- and tri-peptides and , representing the tryptophan core of stephanotic acid, have been synthesized, the key steps being the formation of the phosphono-di- and tri-peptides and by a highly chemoselective rhodium(II) catalyzed carbene N-H insertion reaction, their subsequent Horner-Wadsworth-Emmons reactions with N-Boc-6-bromoindole-3-carboxaldehyde, and the rho...

a series of tri- and tetra- substituted imidazoles were synthesized from benzyl, aldehyde and ammonium acetate in the presence of zeolite as an ecofriendly reusable catalyst under microwave irradiation in the absence of solvent. the yields are high to excellent and the use of microwave irradiation reduces reaction times to few minute.