CNTO 530 is an erythropoietin receptor agonist MIMETIBODYTM construct. CNTO 530 has been shown to be active in a number of rodent models of acquired anemia (e.g. renal insufficiency and chemotherapy induced anemia). We investigated the efficacy of CNTO 530 in murine models of β-thalassemia and sickle cell anemia (Berkeley mice). β- thalassemic mice are deficient in expression of α-globin chain ...

Anemia as associated with numerous clinical conditions can be debilitating, but frequently can be treated via administration of epoetin-alfa, darbepoietin-alfa, or methoxy-PEG epoetin-beta. Despite the complexity of EPO-EPO receptor interactions, the development of interesting EPO mimetic peptides (EMPs) also has been possible. CNTO 530 is one such novel MIMETIBODY Fc-domain dimeric EMP fusion ...

Anemia as associated with numerous clinical conditions can be debilitating, but frequently can be treated via administration of epoetin-alfa, darbepoietin-alfa or methoxy-PEG epoetin-beta. Despite the complexity of EPO-EPO receptor interactions, the development of interesting EPO mimetic peptides (EMPs) also has been possible. CNTO 530 is one such novel MIMETIBODY TM Fc-domain dimeric EMP fusio...

Previous studies in Caenorhabditis elegans showed that RPM-1 (Regulator of Presynaptic Morphology-1) regulates axon termination and synapse formation. To understand the mechanism of how rpm-1 functions, we have used mass spectrometry to identify RPM-1 binding proteins, and have identified RAE-1 (RNA Export protein-1) as an evolutionarily conserved binding partner. We define a RAE-1 binding regi...

Abstract The aim of this study was to evaluate the effect rumen-protected (RPM) supplementation on body temperature, as well relationship between skin thickness and temperature Nelore cows in a tropical climate. carried out at Hildegard Georgina Von Pritzelwitz Agrozootechnical Experimental Station (Fazenda Figueira), located southern Brazil (23º34'26" S; 50º58'14" W), during 2020/2021 breeding...

On different days, 10 men performed 30-min sessions of cycling at 50-55% of their peak oxygen uptake (VO(2)); one at 40 rpm and another at 80 rpm. Rectal temperature, heart rate (HR), mean arterial pressure (MAP), plasma lactate, glucose, insulin, and cortisol were measured before exercise, during the 15th and 30th min of exercise, and at 5 and 10 min postexercise. Rating of perceived exertion ...

Replacing the project manager (RPM) during IT project is a known phenomenon, but surprisingly, few studies have investigated the issue. To improve understanding of the situation in the IT field, we propose a research agenda that aims to provide IT professionals the means to sustainably manage RPM in IT projects. The research agenda is structured in line with the goals of theories in Gregor’s ta...

To whom correspondence should be addressed: Keesook Lee, Ph.D., Hormone Research Center, Chonnam National University, Gwangju, 500-757, Republic of Korea. Phone: +82-62-530-0509; Fax: +82-62-530-0500; E mail: [email protected]. Won-Jea Cho, Ph.D., College of Pharmacy, Chonnam National University, Gwangju 500-757, Republic of Korea. Phone: +82-62-530-2933; Fax: +82-62-530-2911; E mail: wjcho@ch...

Little is known of mechanisms regulating presynaptic differentiation. We identified rpm-1 in a screen for mutants with defects in patterning of a presynaptic marker at certain interneuronal synapses. The predicted RPM-1 protein contains zinc binding, RCC1, and other conserved motifs. In rpm-1 mutants, mechanosensory neurons fail to accumulate tagged vesicles, retract synaptic branches, and ecto...