C ellular communication systems are continuing to incorporate advanced signal processing techniques. Third-generation cellular systems are already widely deployed and are being followed by fourth-generation (4G) systems. Since 4G cellular technology development is considered to have concluded in 2011, the attention of the research community is shifting toward what will be the next set of innova...

Hepatocarcinogenesis is heavily influenced by chronic hepatitis B (HBV) and C (HCV) infection. Elevated levels of plasminogen activator inhibitor-1 (SERPINE1/PAI-1) have been reported in patients with hepatocellular carcinoma (HCC) associated with viral infection. The gene encoding SERPINE1 is highly polymorphic and the frequently associated 4/5 guanosine (4G/5G) polymorphism in the gene promot...

Brain Infarction To the Editor: Roest et al1 reported a nested case-control study that assessed the relation between 4G/5G polymorphism in the plasminogen activator inhibitor (PAI-1) gene and cardiovascular and cerebrovascular mortality in women. The authors found that 4G/4G homozygotes had a decreased risk of dying from stroke compared with 5G/5G homozygotes (relative risk, 0.4; 95% confidence...

BACKGROUND We examined the influence of the 4G/5G PAI-1 (plasminogen activator inhibitor) genotype on Angiotensin II (Ang II)-induced PAI-1 expression by human endothelial cells (HUVEC) in the presence and absence of AT1-receptor blocker losartan, and screened for this polymorphism in relation to plasma PAI-1 and arterial pressure in apparently healthy subjects. METHODS AND RESULTS Genotyped ...

Research on next-generation 5G wireless networks is currently attracting a lot of attention in both academia and industry. While 5G development and standardization activities are still at their early stage, it is widely acknowledged that 5G systems are going to extensively rely on dense small cell deployments, which would exploit infrastructure and network functions virtualization (NFV), and pu...

The antigen content of plasminogen activator inhibitor-1 (PAI-1) in primary breast cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumors predict poor prognosis for patients. The gene encoding PAI-1 is highly polymorphic and an insertion (5G)/deletion (4G) polymorphism in the PAI-1 gene promoter (the 4G/5G polymorphism), may have functional significance in PAI-...

METIS (Mobile and wireless communications Enablers for the Twenty-twenty Information Society) is the EU flagship 5G project having the objective to lay the foundation for 5G systems and to build consensus prior to standardization. The METIS overall approach towards 5G builds upon the evolution of existing technologies complemented by new radio concepts that are designed to meet the new and chal...

In the recent years, the demand for higher data rates has been continuously growing to satisfy consumers’ desire for a faster, safer, and smarter wireless network. Since current wireless systems are facing a bottleneck in spectrum resources which make it difficult to enhance performance in the limited available bandwidth. To overcome this problem new Generation of mobile communication known as ...

The Next Generation of mobile network 5G, which will be based on a high-speed wireless broadband connection, could bring important changes to the way individuals and businesses employ telecommunications services and solve the issues related to the explosive growth in demand for mobile traffic, and the profitability decreasing of the mobile Broadband market. Therefore, the OMNs (Operator Mobile ...

2'-Fluoro-3-(substituted pyridine)epibatidine analogues 7a-e and 8a-e were synthesized, and their in vitro and in vivo nAChR properties were determined. 2'-Fluoro-3'-(4″-pyridinyl)deschloroepibatidine (7a) and 2'-fluoro-3'-(3″-pyridinyl)deschloroepibatidine (8a) were synthesized as bioisosteres of the 4'-nitrophenyl lead compounds 5a and 5g. Comparison of the in vitro nAChR properties of 7a and...