This study evaluated the toxicity profiles of temozolomide in the treatment of malignant glioma as either concurrent or adjuvant chemotherapy. We retrospectively reviewed the medical records of 300 malignant glioma patients treated with temozolomide in two medical institutions in Korea between 2004 and 2010. Two hundred nine patients experienced a total of 618 toxicities during temozolomide the...

6 Rina P. M. Wong, Harin Karunajeewa, Ivo Mueller, Peter Siba, Peter A. Zimmerman, 7 Timothy M. E. Davis 8 9 1. School of Medicine and Pharmacology, Fremantle Unit, University of Western 10 Australia, Nedlands, Western Australia, Australia. 11 2. Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea. 12 3. The Center for Global Health and Diseases, Case Western Reserve Univer...

We examine the optimal regulatory policy for a risk-averse …rm when the …rm is imperfectly informed about its e¢ ciency parameter for a project at the time of contracting. The …rm’s risk aversion shifts the optimal regulatory policy from a …xed-price contract to a cost-plus contract. The optimal regulatory policy entails undere¤ort by an ine¢ cient …rm as in Lafont and Tirole (1986) and the e¤o...

We examine the e¤ect of an imperfect audit and a subsequent appeals process in a standard adverse selection problem when legal or institutional restrictions impose an upper bound on penalties. We show that the imperfect audit always reduces the agent’s information rent and enhances e¢ ciency despite the limited liability. A subsequent appeals process, which allows the agent to challenge an unfa...

Cyanobenzenes have recently been suggested as good candidates for the detection of aromatic molecules in interstellar space [1–3], partly due to their large dipole moments. The simplest molecule from this class is benzonitrile (C6H5CN), which might be detectable, for example, in the proto-planetary nebula CRL 618 [1, 2]. These predictions are based on an assumed abundance of 10 and a dipole mom...

We report the detection of direct ℓ-type transitions towards the proto-planetary nebula CRL 618 during a study of vibrationally excited carbon chains. ∆J = 0 transitions of HCN in its first excited bending mode v 2 = 1 were detected in absorption against the continuum of the central H ii region making use of the Effelsberg 100 m telescope and the Very Large Array. Additionally, the J = 9 direct...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 607 1. Restless Legs Syndrome (RLS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 608 1.1 Diagnosis of RLS . . . . . . . . . . . . . . . . . . . . . . . ...

Scaling rain attenuation parameters will significantly benefit the quick monitoring of in a particular channel with previously known results or situ setup measurements. Most scaling techniques have been derived for slant links. In this study, we also applied frequency and polarization terrestrial link applications. We collected real measured datasets from research paper publications examined th...