To understand the molecular mechanism of ligand-induced gating of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)/Ca(2+) release channel, we analyzed the channel properties of deletion mutants retaining both the IP(3)-binding and channel-forming domains of IP(3)R1. Using intrinsically IP(3)R-deficient cells as the host cells for receptor expression, we determined that six of the muta...

stituent of marijuana, Cannabis sativa L. It is well known that THC is oxidized to a number of metabolites in the liver of mammals. Recent studies have clarified that P450 plays a major role in the oxidation of THC. We have previously reported that a hepatic microsomal enzyme, named microsomal alcohol oxygenase (MALCO), is able to oxidize 7aand 7b-hydroxy-D-THC to 7-oxo-D-THC in the presence of...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 650 1. Physiological Control of Gastrointestinal Motility . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 651 1.1 Stimulation of Gastrointestinal Contractions . . . . . . . . . . . . . . . ...

A learner who can solve a problem cannot always understand the problem adequately. In order to deeply understand a problem, it is necessary that he/she poses various problems which can be solved by the “solution method” of the problem. Moreover, after he/she poses problems, it is necessary that he/she considers and indicates differences between the problems posed by him/her, too. So, we develop...

Spanning 30 years and 40 individual videogames across a range of platforms, Pac-Man is one of the most recognizable of all videogame characters and a pop–culture icon. In spite of its widespread popularity, the game receives little sustained academic engagement or analysis. In an attempt to address this, the paper argues that in its classic iterations PacMan generates complex notions of space a...

Paralinguistics organizers such as parenthesis, footnotes, and pop-up fields on screen, should play an important role signalling the writer’s “minimization” intention when secondary points are concerned. This experiment investigated the role of pop-up fields compared to brackets in an information retrieval task. The results showed that, in this kind of task, putting secondary pieces of informat...

Mesothoracic wings have been examined and compared in 32 species representing 20 genera of Afrotropical Scutelleridae. Morphological characters of the corium are described. Three main types of mesothoracic wing venation patterns can be recognized. The taxonomic significance of forewing characters in Scutelleridae is briefly discussed.