The term “the three Rs” in science refers to replacement, reduction, and refinement, a set of guiding principles for more humane use of animals in research and testing: replacement of animals with nonsentient alternatives; reduction of the number of animals used to the minimum consistent with achieving the scientific objectives; and refinement of scientific procedures and husbandry to minimize ...

I n recent issues of The Journal several articles have appeared which decribe The American Chestnut Foundation’s breeding program for backcrossing the blight resistance of Chinese chestnut into American chestnut (Hebard 1994a). The breeding program involves repeated crossing of selected C. dentata x C. mollissima hybrids and progeny to C. dentata (American chestnut), hence reconstituting the C....

Michela Faggioni, Hyun Seok Hwang, Christian van der Werf, Ineke Nederend, Prince J. Tachycardia in Mice and in Patients Accelerated Sinus Rhythm Prevents Catecholaminergic Polymorphic Ventricular Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX ...

This article demonstrates how to develop a Microchip PIC16F84 based device that supports RS-232 interface with PC. Circuit (LED Board) design and software development will be discussed. PicBasic Pro Compiler from microEngineering Labs, Inc. is used for PIC programming. Development of LED Board Control Console using C/C++ is also briefly discussed. The project requires basic work experience with...

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PURPOSE There is currently no information regarding predisposing factors for chronic and recurrent rhinosinusitis (RS), although these are considered to be multifactorial in origin, and allergic diseases contribute to their pathogenesis. We evaluated the predisposing factors that may be associated with chronic and recurrent RS. METHODS In this prospective study, we examined patients with RS y...

─The purpose of this study was to explore the related practical techniques of monitoring and controlling system in designing renewable energy system, especially for Small-scaled wind-power generator. Recently, the whole world was actively developing replaced energy to solve the economic development and daily-life necessities problems resulting from gradually lacking of oil. Taiwan government wa...

restraint-induced stress (rs) increases histamine concentration in the brain. there is no previous report regarding the role of histamine receptors in immunomodulatory effect of rs. in the present study the role of brain histamine receptors on reduction of humoral and cellular immune function induced by rs was evaluated. for this purpose male wistar rats (200-250 g) were immunized with sheep re...

PURPOSE To assess the feasibility of diffusion tensor imaging (DTI) using simultaneous multislice (SMS) acquisition with blipped controlled aliasing in parallel imaging (CAIPI) for accelerated readout-segmented echo planar imaging (rs-EPI) of the mandibular nerves. DTI of the mandibular nerves using EPI is challenging due to susceptibility artifacts. Rs-EPI is less prone to artifacts but associ...