Abstract Introduction The low blood flow in ischemic stroke reduces oxygen and glucose induces a series of reactions that produce free radicals. Free radicals can destroy cell membranes (lipid peroxidation) marked by the elevation malondialdehyde (MDA), damage deoxyribonucleic acid (DNA) showed 8-hydroxy-2’-deoxyguanosine (8-OHdG). This review aimed to assess conclude research-based study syste...