Objective (s): SN38 is the prominent and effective anticancer drug for treating various types of human cancers such as colorectal, ovarian and lung cancers. SN38 is highly toxic, and due to its poor solubility in aqueous media, and low stability and hydrolysis at physiological pH, it has not been used as an anti-cancer drug. To overcome these problems, SN38 was conjugated with new nanocarriers ...

Reliable and robust diode-pumped solidstate oscillators and amplifiers with high output power, high efficiency and good beam quality are required in numerous industry applications and research areas (W. Koechner, 2007). Integral part of these systems is the diode-pumped laser module (chamber), whose characteristics determine to large extend the output parameters of the entire laser setup. For h...

AIM To study the optical properties of human normal small intestine tissue at 476.5 nm, 488 nm, 496.5 nm, 514.5 nm, 532 nm, 808 nm wavelengths of laser irradiation. METHODS A double-integrating-sphere system, the basic principle of measuring technology of light radiation, and an optical model of biological tissues were used in the study. RESULTS The results of measurement showed that there ...

Suture ligation of blood vessels during surgery can be time-consuming and skill-intensive. Energy-based, electrosurgical, and ultrasonic devices have recently replaced the use of sutures and mechanical clips (which leave foreign objects in the body) for many surgical procedures, providing rapid hemostasis during surgery. However, these devices have the potential to create an undesirably large c...

Spectral properties of sign symmetric matrices are studied. A criterion for sign symmetry of shifted basic circulant permutation matrices is proven, and is then used to answer the question which complex numbers can serve as eigenvalues of sign symmetric 3 × 3 matrices. The results are applied in the discussion of the eigenvalues of QM -matrices. In particular, it is shown that for every positiv...

We consider classes of models related to those introduced by Lehmann in 1953 and Sklar in 1959. Recently developed algorithms for finding profile NP likelihood procedures are discussed, extended and implemented for such models by combining them with the MM algorithm. In particular we consider statistical procedures for a regression model with proportional expected hazard rates, and for transfor...

A novel, facile and efficient method was developed for the activation of acetic acid modulated zirconium MOFs. The protocol involves briefly heating the material in water using microwave irradiation. MOF-808, DUT-84 and UiO-66 were all activated in this manner to remove the modulator and organic solvent from the framework post synthesis, with retention of MOF integrity post activation. The degr...

Recently, incorporating multiple components into one nanostructured matrix to construct a multifunctional nanomedical platform has attracted more and more attention for simultaneous anticancer diagnosis and therapy. Herein, a novel anti-cancer nanoplatform has been successfully developed by coating a uniform shell of poly(acrylic acid) (PAA) on the surface of CuS-decorated upconversion nanopart...

To integrate photothermal therapy (PTT) with chemotherapy for improving anticancer efficiency, we developed a novel and multifunctional doxorubicin (DOX) conjugated copper sulfide nanoparticle (CuS-DOX NP) drug delivery system using hydrazone bonds to conjugate carboxyl-functionalized copper sulfide nanoparticles (CuS NPs) and DOX. On the other hand, the hydrazone bonds could be used for improv...