Recent success in wavelet image coding is mainly attributed to recognition of the importance of data organization and representation. There have been several very competitive wavelet coders developed, namely, Shapiro's embedded zerotree wavelets (EZW), Servetto et al.'s morphological representation of wavelet data (MRWD), and Said and Pearlman's set partitioning in hierarchical trees (SPIHT). I...

OBJECTIVE Restriction analysis is a straightforward procedure for mutational analysis. It is commonly used for screening RET mutations. Incomplete digestion is a well-known cause of false results. Herein, we report another limitation of the method. DESIGN AND METHODS Screening for somatic mutations in RET exons 16, 13 and 15 was performed in a patient with a sporadic medullary thyroid carcino...

This paper continues the convergence analysis in [M. Giles and S. Ulbrich, SIAM J. Numer. Anal., 48 (2010), pp. 882–904] of discrete approximations to the linearized and adjoint equations arising from an unsteady one-dimensional hyperbolic equation with a convex flux function. We consider a simple modified Lax–Friedrichs discretization on a uniform grid, and a key point is that the numerical sm...

BACKGROUND Aripiprazole lauroxil is an extended-release prodrug of aripiprazole for intramuscular injection, approved for schizophrenia treatment. We developed a population pharmacokinetic (PopPK) model to characterize aripiprazole lauroxil PK and evaluate dosing scenarios likely to be encountered in clinical practice. METHODS Data from 616 patients with schizophrenia, collected from 5 clinic...

PRL/v96/i3/e030201 [8] Baldassi C, Braunstein A, Brunel N and Zecchina R 2007 Proceedings of the National Academy of Sciences 104 11079–11084 ISSN 0027-8424, 1091-6490 PMID: 17581884 URL http://www.pnas.org/ content/104/26/11079 [9] Baldassi C 2009 Journal of Statistical Physics 136 ISSN 0022-4715 (Print) 1572-9613 (Online) URL http://www.springerlink.com/content/r07772l167526045/ [10] Mézard, ...

Background KRAS is the most frequently mutated oncogene, yet mutant has historically been a challenging target for conventional small molecule drug development. Tumour specific neoantigen peptides derived from are presented by cell surface human leucocyte antigens (HLA) and form class of shared, tumour-specific that attractive targets immunotherapy. Methods A T clone specifically recognizes com...