CONTEXT Controversy exists as to whether lipoprotein(a), a lipoprotein with homology to plasminogen, is a clinically meaningful cardiovascular risk marker in women. There is also poor agreement among lipoprotein(a) levels obtained by different assays. OBJECTIVE To determine the association of lipoprotein(a) levels, measured with an assay independent of apolipoprotein(a) isoform size, with the...

An audio version of this article is available at NEJM.org A 13-year-old boy visits his pediatrician because his school football team requires medical clearance before the start of the season. On physical examination, his weight is 72 kg (above the 99th percentile for age and sex) and his height is 155 cm (the 50th percentile); his body-mass index (the weight in kilograms divided by the square o...

Abstract In July 2011, the Pakistani public learnt that Central Intelligence Agency (CIA) had used a vaccination campaign as cover to capture Osama Bin Laden. The Taliban leveraged on this information and launched an anti-vaccine propaganda discredit vaccines workers. We evaluate effects of these events immunization by implementing difference-in-differences strategy across cohorts districts. fi...

Orthopedic trauma surgery is a critical component of resident education. Surgical case logs obtained from the Accreditation Council of Graduate Medical Students from 2009 to 2013 for orthopedic surgery residents were examined for variability between the 90th and 10th percentiles in regards to the volume of cases performed. There was an upward trend in the mean number of cases performed by senio...

OBJECTIVE The aim of the paper is to assess changes in nutritional status of a selected group of children from urban and rural environment in Upper Silesia in the intervening 5 years. MATERIALS AND METHODS The study was conducted twice - in 2003 and during the school year 2008/2009, and involved children from the town of Bytom and from the village Boronów. To assess the nutritional status, th...

Background Enlargement of the aorta or main pulmonary artery (MPA) is associated with cardiopulmonary disease, and an increased MPA-to-ascending aorta ratio is associated with pulmonary hypertension. We sought to determine mean and upper 90th percentile (p90) diameters of the thoracic and abdominal aorta and MPA in a longitudinally-followed adult cohort without clinical cardiopulmonary disease.

Introduction This study investigated whether individual-level social capital modifies the association between adverse childhood experiences and dementia onset. Methods A 3-year follow-up (2013–2016) was conducted among participants who were physically cognitively independent in Japan Gerontological Evaluation Study. Dementia incidence for 16,821 assessed through public long-term care insurance ...

Using new specific and sensitive enzyme-linked immunosorbent assays for inhibin A and inhibin B, we measured these proteins in amniotic fluid (AF), maternal serum (MS), and umbilical cord serum in normal pregnancies. Inhibin A levels in AF rose from a median (10-90th percentile) level of 615 (158.2-1124.6) pg/mL at 14 weeks to 1336.0 (489.4-2084.1) pg/mL at 20 weeks, and inhibin B rose from 216...

BACKGROUND AND PURPOSE Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging modalities do not effectively differentiate them. We aimed to examine the use of DWI and T1-weighted dynamic contrast-enhanced-MR imaging as potential discriminative tools. MATERIALS AND METHODS We retrospectively ...