Chromaffin cells express N-type calcium channels identified on the basis of their high sensitivity to block by v-conotoxin GVIA (v-CgTx GVIA). In contrast to neuronal N-type calcium currents that inactivate during long depolarizations and that require negative holding potentials to remove inactivation, many chromaffin cells exhibit N-type calcium channel currents that show little inactivation d...

[1] This study examines the effects of future anthropogenic emissions on climate, and the resulting feedback to natural emissions and air quality. Speciated sectorand region-specific 2030 emission factors were developed to produce gas and particle emission inventories that followed Special Report on Emission Scenarios (SRES) A1B and B1 emission trajectories. Current and future climate model sim...

We have shown previously that the Ca channel b3 subunit is capable of modulating tonic G-protein inhibition of a1A and a1B Ca channels expressed in oocytes. Here we determine the modulatory effect of the Ca channel b3 subunit on M2 muscarinic receptor-activated G-protein inhibition and whether the b3 subunit modulates the G-protein sensitivity of a1A and a1B currents equivalently. To compare th...

. introduction global warming and its result, climate change is an important subject investigated especially in the recent decades by researchers throughout the world. in these studies, at first, climatic parameters changes are investigated. considering many uncertainties in the parameters estimation, it is better to choose a method in order to study and analyze the uncertainty band due to diff...

it is increasingly recognized that the land-use change, especially urbanization has influenced hydrological attributes intensely. but in most urban designs, flood prediction is considered through type of land use (residential, industrial, and so on) and density. however, experiences show that this method has not been very successful. as a result, the present study aims to investigate and explor...

To investigate a1B-adrenoceptor function, we developed a phosphorothioate antisense oligodeoxynucleotide (AO) to inhibit the expression of the a1B-adrenoceptor subtype in DDT1 MF2 cells. We measured the cellular uptake of the AO and its effect on a1B-adrenoceptor mRNA expression, protein density, and coupling to phospholipase C. Cells treated with either a control oligodeoxynucleotide (CO) or m...

introduction numerous studies have demonstrated the relationship between the amount of co2 in the atmosphere and climate change. in this respect, developed countries have an undeniable role and cause serious damage to earth environment throughout the world. ipcc’ forth evaluation report implies that adding greenhouse gases to the atmosphere during recent decades prevents the heat rays to emit w...

Selective inactivation of a1B-adrenoceptor (AR) by the sitedirected alkylating agent chlorethylclonidine (CEC) has been used as one of major pharmacological criteria to subclassify a1-AR; however, the mechanism for the differential CEC sensitivity of the two subtypes is uncertain, and the extent of CEC inactivation varies depending on the treatment employed. In this study, we examined the corre...

1Department of Ophthalmology, Valiaser Hospital; 2Nursing College, Birjand Medical University, Birjand, Islamic Republic of Iran. 3Department of Ophthalmology, Mashhad University of Medical Science, Mashhad, Islamic Republic of Iran. Received: 09/05/03; accepted: 20/10/03 ABSTRACT To investigate the possible relationship between hyperhomocysteinaemia and retinal vascular occlusion, we measured ...