OBJECTIVE To determine if 3 months of preoperative gonadotropin-releasing hormone agonist (GnRH-a) treatment decreases postoperative uterine adhesions after open abdominal surgery for the removal of uterine fibroids. DESIGN Prospective, randomized, clinical study. SETTING A tertiary care medical center. PATIENT(S) Women of reproductive age with symptomatic uterine fibroids not amenable to...

some formulations of drug in adhesive transdermal drug delivery systems ()tddss)( with different functional and non-functional acrylic pressure sensitive adhesives psas)( were prepared. for this purpose fentanyl was used as a drug component. the effects of psas type on skin permeation and in vitro drug release from devices were evaluated using hydrodynamically well-characterized chien permeatio...

BACKGROUND Postoperative adhesions have proven to be intractable complications after abdominal operations. This study assessed the efficacy of N, O - carboxymethyl chitosan (NOCC) to limit adhesion formation and re-formation in a rabbit abdominal surgery model. METHODS In study 1 (adhesion formation), injuries to the large bowel, cecum, and abdominal sidewall were generated in rabbits. The ra...

intussusception is a common pediatric surgical emergency, but rarely seen postoperatively as a cause of obstruction. this complication occurs after abdominal, thoracic, orthopaedic and urologic operations. ileus and obstruction due to adhesion band are the common causes of postoperative obstruction, however, although intussusception is less frequent but can be serious. we have to consider this ...

The intestine function recovery decoction (IFRD) is a traditional Chinese medicine that has been used for the treatment of adhesive intestinal obstruction. In this study, the preventative effects and probable mechanism of the IFRD were investigated in a rat model. We randomly assigned rats to five groups: normal, model, control, low dose IFRD, and high dose IFRD. In the animal model, the caecum...

BACKGROUND Intra-abdominal adhesions remain a major clinical problem. Previously, rifamycin lavage was used to prevent adhesion formation in the septic abdomen. The aim of our study was to test the effectiveness of intraperitoneal application of alternate antibiotics in an abdominal sepsis model. METHODS Sixty Wistar-albino rats were randomly divided into 6 equal groups. Bacterial peritonitis...

Accessible online at: www.karger.com/dsu We have followed with interest the publications of Swank et al. [1] concerning surgical adhesion-reduction strategies for the management of pelvic pain and wish to respond to their latest article, published in January 2004, which discusses the incidence/ extent of intra-abdominal adhesion formation/reformation following laparoscopic adhesiolysis. The rol...