lymphatic metastasis to abdominal lymph nodes. The patient received 1 course of platinum-containing chemotherapy, but the response was evaluated as progressive disease. The abdominal lymph nodes grew up to 30 mm in size. She died of lung cancer 2 months after the chemotherapy. Direct lymphatic metastasis to abdominal lymph nodes without involvement of lobar, hilar, or mediastinal lymph nodes is...

1 of 2 DESCRIPTION A 57-year-old Polish gentleman presented with persistent upper abdominal pain exacerbated by eating. Abdominal ultrasound scan performed in Poland showed a 4.4 cm mass in the region of the abdominal aorta reported as an abdominal aortic aneurysm. Subsequent CT imaging demonstrated a normal calibre aorta, surrounded by a soft tissue mass in conjunction with left-sided hydronep...

Although high dose ionizing radiation (>100 mSv) harms humans, particularly (but not exclusively) concerning cancer, the effect of lower radiation doses is less clear. Low dose radiation exposure is of societal importance in relation to screening tests for cancer and occupational radiation exposure, as two examples. Inflammatory bowel disease (IBD) patients and cancer survivors undergo multiple...

Hyperthermic intraperitoneal chemotherapy is effective in treating various intra-abdominal malignancies. However, this therapeutic modality can only be performed during surgical operations and cannot be used repeatedly. We propose repeatedly noninvasive hyperthermia mediated by pegylated silica-core gold nanoshells (pSGNs) in vivo with external near-infrared (NIR) laser irradiation. This study ...

Second malignant neoplasms (SMN) are therapy-induced malignancies and a growing problem in cancer survivors, particularly survivors of childhood cancers. The lack of experimental models of SMNs has limited understanding of their pathogenesis. It is currently not possible to predict or prevent this devastating late complication. Individuals with neurofibromatosis I (NF1) are at increased risk of...

Second malignant neoplasms (SMN) are therapy-induced malignancies and a growing problem in cancer survivors, particularly survivors of childhood cancers. The lack of experimental models of SMNs has limited understanding of their pathogenesis. It is currently not possible to predict or prevent this devastating late complication. Individuals with neurofibromatosis I (NF1) are at increased risk of...

We investigated whether radiation-induced pica, a behavior characterized by the eating of a non-food substance, such as kaolin, can be used as an index of radiation-induced vomiting in rats. Since there was an individual difference in the susceptibility to pica, we selected rats that actually ate kaolin following X-ray irradiation, and used them for the experiment. The total-body irradiation (T...

OBJECTIVE The aim of the study was to evaluate the role of ramosetron for the prevention of chemoradiotherapy-induced nausea and vomiting (CRINV) in patients receiving upper abdominal irradiation with concurrent 5-fluorouracil chemotherapy. METHODS Between November 2006 and April 2007, 25 patients with pancreatico-biliary cancer underwent adjuvant chemoradiotherapy. A total dose of 40 Gy was ...

Stable mixed donor/host hematopoietic chimerism can be accomplished in dog leukocyte antigen (DLA)-identical littermate dogs given sublethal (200 cGy) total-body irradiation (TBI) before and immunosuppression with mycophenolate mofetil (MMF) and cyclosporine (CSP) after transplant (Blood 89:3048, 1997). Studies were based on the hypothesis that drugs that prevent graft-versus-host disease (GVHD...