Liver disease, particularly alcoholic cirrhosis, is associated with a number of interesting chemical changes which result in structural and metabolic abnormalities of the erythrocyte membrane leading to microscopically observable cell shape changes and hemolytic anemia varying from very mild to potentially lethal. Increase in unesterified serum cholesterol owing to lecithin cholesterol acyl tra...

Synthesis of bi functionally substituted thieno[2,3-c]pyrazole compounds was carried out by a new method. The substituted group at position five is namely (carbonitrile, carboxamide, N-(substitutedphenyl) carboxamide and benzoyl group). Chloroacetylation of the amino thieno[2,3-c]pyrazolecarboxamide compound afforded the chloroacetyl amino derivative. The chemical structure of the newly synthes...

Phikud Navakot (PN), Thai herbal remedy in National List of Essential Medicines, has been claimed to reduce many cardiovascular symptoms especially dizziness and fainting. Apart from blood supply, erythrocyte morphology, in both shape and size, is one of the main consideration factors in cardiovascular diseases and may be affected by vascular oxidative stress. However, little is known about ant...

A diagnosis of spur cell anemia was made. Spur cell anemia is found in end-stage alcoholic liver disease. The morphologic changes of spur cells are caused by accumulation of excess membrane cholesterol, leading to an impaired deformability and consequently a reduced red cell survival. The prognosis of patients with spur cell anemia is poor, with a median survival of a few months. Liver transpla...

By means of Surface Evolver (Exp. Math,1,141 1992), a software package of bruteforce energy minimization over a triangulated surface developed by the geometry center of University of Minnesota, we have numerically searched the non-axisymmetric shapes under the Helfrich spontaneous curvature (SC) energy model. We show for the first time there are abundant mechanically stable non-axisymmetric ves...

INTRODUCTION Klippel-Trenaunay syndrome is a rare congenital mesodermal abnormality characterized by bone and soft tissue hypertrophy, extensive hemangioma and venous abnormalities. We report the case of a patient with two additional rare clinical manifestations in the background of Klippel-Trenaunay syndrome, namely, acanthocytosis and splenic and retroperitoneal lymphangioma. CASE PRESENTAT...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 65-year-old man presented with a 5-day history of fever. He took an antimalarial drug (Fansidar;sulfadoxine/ pyrimethamine) without being tested for malarial parasite. and corrected reticulocyte count, 20%. Peripheral blood smear (PBS) displayed numerous b...

A 40-year-old HIV-positive man was evaluated for fatigue, weakness, fever, and cough. He was not taking any medications. His blood count showed normocytic anemia, leukopenia, and thrombocytopenia (hemoglobin 85.0 g/L, mean corpuscular volume 99 fL, white blood cell count 1.9 109/L, platelets 50 109/L). His CD4 count was 0.05 109/L. Other laboratory tests showed normal B12, folate, thyroid, and ...

We report the autopsy of a 79-year-old Japanese woman with Dubin-Johnson syndrome accompanied by pneumonia, an abetalipoproteinemia-like lipid profile and acanthocytosis. On admission, physical examination of the patient revealed malnutrition. Blood tests revealed marked inflammatory changes and mild liver dysfunction. Chest X-ray indicated bilateral pneumonia. Total cholesterol, low-density li...

Delahunty R, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220775 Description A 77-year-old Caucasian man presented to the oncology service with de novo v-raf murine sarcoma viral oncogene homolog B (BRAF), wild-type metastatic melanoma and widespread disease involving; subcutaneous fat, lymph nodes, bone and spleen with no history of autoimmunity. At diagnosis, the spleen was measured within ...