Hypohidrotic ectodermal dysplasia (HED) is characterized by defective ectodermal organ development. This includes the salivary glands (SGs), which have an important role in lubricating the oral cavity. In humans and mice, HED is caused by mutations in Ectodysplasin A (Eda) pathway genes. Various phenotypes of the mutant mouse Eda(Ta/Ta), which lacks the ligand Eda, can be rescued by maternal in...

Adolescence is characterized by increases in both perceived stress and risk-taking, although the effects of stress on risk-sensitive decision-making have received little attention in adolescent groups. We report psychophysiological data from the healthy control group of a larger project examining neuroendocrine and neuropsychological function in boys with conduct disorder. The present analysis ...

A novel stable donor/acceptor-supported MnI-metallasilanone 3 was synthesized. The intramolecular silanone-MnI interaction induces a highly strained three-membered cyclic structure, leading to an exceptionally high reactivity of as donor/acceptor complex silanone. Indeed, metallasilanone readily reacts with various small molecules such H2 or ethylene gas in mild conditions.

Non-covalent interactions are the main forces involved in the recognition, transport and regulation of virtually all events in biological systems [1]. Although the chemical relevance of anionic molecules is very defined, the chemistry of anion receptors is still a growing area [2]. Host molecules which can interact with anionic species through non-covalent interactions have some advantages due ...

In our previous work we have introduced EDA-ILP, an Inductive Logic Programming (ILP) system based on Estimation Distribution Algorithm (EDA). EDA-ILP showed to be superior when compared to GA-ILP, a variation of EDA-ILP created replacing the EDA by a “conventional” Genetic Algorithm. Additionally, EDA-ILP proved to be very competitive when compared to the state of the art ILP system Aleph. Thi...

Carbonyl-carbonyl interactions between adjacent backbone amides have been implicated in the conformational stability of proteins. By combining experimental and computational approaches, we show that relevant amidic carbonyl groups associate through an n→π* donor-acceptor interaction with an energy of at least 0.27 kcal/mol. The n→π* interaction between two thioamides is 3-fold stronger than bet...

The intermolecular (outer sphere, OS) interaction of a reducing and an oxidizing metal complex generates a new optical transition involving charge transfer (CT) from the electron donor to the acceptor. OS C T transitions are classified according to the redox site (metal or ligand). Generally, the interaction between donor and acceptor is facilitated by ion pairs consisting of an oxidizing compl...

Electrodermal activity (EDA) recordings are widely used in experimental psychology to measure skin conductance responses (SCRs) that reflect sympathetic nervous system arousal. However, irregular respiration patterns and deep breaths can cause EDA fluctuations that are difficult to distinguish from genuine arousal-related SCRs, presenting a methodological challenge that increases the likelihood...

EDA HAS BEEN AN IMMENSELY successful field, helping to manage the exponential increase in our capability to implement ICs that incorporate billions of transistors. At the same time, EDA has fostered and applied theories of computation and modeling, successfully combining them with practice. EDA has completely transformed the way that electronics engineers design and manufacture ICs. It was one ...

Anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) is characterized according to its various manifestations, which include ectodermal dysplasia, vascular anomalies, osteopetrosis, and diverse immunological abnormalities such as susceptibility to pathogens, impaired antibody responses to polysaccharides, hypogammaglobulinemia, hyper-IgM syndrome, impaired natural killer cell cytotoxi...