This article examines the evidence justifying the use of angiotensin-converting enzyme (ACE) inhibitors as first-line antihypertensive drugs. ACE inhibitors are as effective as traditional antihypertensive agents and, in addition, exert their blood-pressure-lowering effect with near optimal hemodynamic alterations. These drugs have a good tolerance and safety profile although they induce cough ...

Ezekowitz et al. (1) recently reported lack of benefit of angiotensin-converting enzyme (ACE) inhibitors on mortality in patients with chronic heart failure (CHF) in whom estimated creatinine clearance was below 60 ml/min, as opposed to a beneficial effect in those with creatinine clearance above 60 ml/min. The researchers attribute this lack of benefit to a possible interaction between aspirin...

BACKGROUND Hyperkalemia is a potentially life-threatening complication resulting from the use of angiotensin-converting enzyme (ACE) inhibitors; data to guide the intensity of monitoring for or responding to hyperkalemia in outpatients are limited. METHODS Case-control methodological procedures were used to identify risk factors for hyperkalemia. Outpatients prescribed ACE inhibitors during 1...

OBJECTIVES This study sought to assess the effect of angiotensin-converting enzyme (ACE) inhibitors and beta-blockers on all-cause mortality in patients with left ventricular (LV) systolic dysfunction according to gender, race, and the presence of diabetes. BACKGROUND Major randomized clinical trials have established that ACE inhibitors and beta-blockers have life-saving benefits in patients ...

Introduction: Cytokines production as one of the inflammatory pathways in CNS is responsible for most brain damages following ischemia. On the other hand, during inflammation and brain ischemia, most of the renin- angiotensin components (RAS) increase locally. While it is established that blockade of RAS especially AT1 receptors has a protective effect on ischemia, the interaction of cytokines ...

Background: The role of Renin Angiotensin System (RAS) in ischemic/reperfusion (I/R) injuries is not fully elucidated. Furthermore, it is not clear whether inhibition of RAS by Angiotensin-Converting Enzyme (ACE) inhibitors has beneficial effects in terms of protecting the brain from I/R injuries. In this study enalapril is used as an ACE inhibitor to evaluate the role of RAS in I/R injuries in...

Angiotensin-converting enzyme (ACE) inhibitors reduce the risk of recurrent myocardial infarction in patients with left ventricular dysfunction. Tissue factor (TF), the initiator of blood coagulation, plays a pivotal role in arterial thrombosis that occurs after atherosclerotic plaque fissuring. Because monocytes synthesize TF and contain several components of the renin-angiotensin system, we i...

Hypertension is a very important problem around the world. The inhibition of Angiotensin-converting enzyme (ACE, EC.3.4.15.1.) regarded as fundamental hypertension treatment. But, synthetic ACE inhibitors have several side effects. For this reason, there are lots studies to improve green inhibitors. Therefore, study was designed determine potential inhibitory effects two members Apiaceae, Coria...

OBJECTIVE To determine the effects of angiotensin converting enzyme (ACE) inhibitors in hypertensive patients with aortic valve stenosis (AS). DESIGN Observational, drug withdrawal, single blinded study, with randomisation of the order of tests. SETTING Hypertension and asymptomatic AS. PATIENTS AND INTERVENTIONS 20 patients (aged 73 (9) years, valve area 0.7 (0.3) cm2, left ventricular e...