It has been shown (1, 2) that in human milk there are N-acetyl-n-glucosamine-containing oligosaccharides which promote the growth of Lactobacillus bifidus var. Penn. In the search for substances with lower molecular weight which would still show a growth-promoting effect in the microbiological test, activity was found in mildly hydrolyzed chitin of crab and lobster shells,’ in P-methyl N-acetyl...

N-acetyl-B-D-Glucosaminidase was purified by affinity and ionexchange chromatography. Two major, A and B, and three minor intermediate forms were isolated and characterized. NAG-A and NAG-B were purified 440 and 1200 fold with final yields of 16 and 23 percent respectively. Each activity was represented by a single protein band. After 70 min preincubation at 55°C a loss of70% activity of N...

In this study it could be shown that in rat the normally occurring N-acetyl neuraminic acid can be modified in its N-acyl moiety by in vivo administration of the chemically synthesized N-propanoyl precursors, N-propanoyl-D-glucosamine or N-propanoyl-D-mannosamine. It could be shown that each of these nonphysiological amino sugar analogues was incorporated into both membrane and serum glycoprote...

Cystic hydatid disease is caused by cystic larval (metacestode) stages of Echinococcus granulosus. This parasite can potentially occur all over the world especially in Mediterranean and Middle East countries and some parts of Africa, Latin America and China which have major foci of human infections. The cyst wall of metacestodes consists of inner, middle and external layers. To date, little att...

Previous reports indicate that N-acetyl-d-glucosamine oligomers (chitin oligosaccharide; NACOS) and d-glucosamine oligomers (chitosan oligosaccharide; COS) have various biological activities, especially against cancer and inflammation. In this review, we have summarized the findings of previous investigations that have focused on anticancer or anti-inflammatory properties of NACOS and COS. More...

The purified capsids of echovirus I2 were found to contain radioactivity when radioactive glucosamine was provided for virus-infected cultures. Radioactivity was identified with glucosamine, after recovery from the virus particles by acid hydrolysis and paper chromatography. Although the label was not removable from the isolated virus particles without destruction of virus, polyacrylamide gel e...

N-Acetyl-d-neuraminic acid (NeuAc), a well-known and well-studied sialic acid, is found in cell surface glycolipids glycoproteins, where it performs variety of biological functions. The use NeuAc as nutraceutical for infant brain development an intermediate pharmaceutical production demands its on industrial scale. Natural extraction, chemical synthesis, enzymatic biosynthesis are the methods u...