Highly-integrated distributed systems such as Intel Micro Server and SeaMicro Server are increasingly becoming a popular server architecture. Designers of such systems face interesting memory hierarchy design challenges while attempting to reduce/eliminate the notorious disk storage swapping. Disk swapping activities slow down applications’ execution drastically. Swapping to the free remote mem...

A testing method and on-chip testing circuits for our VLSI chip of asynchronous communication mechanism (ACM) using self-timed circuits are presented in this paper. The three properties of ACMs, asynchrony, coherence and freshness, are what we want to test. Besides these, the general function of the chip and data loss are also of interest. Although this work is a specific solution for a specifi...

INTRODUCTION Cell-seeded natural scaffolds derived from acellular matrices (ACMs) hold great promise for tissue-engineering large soft-tissue organs such as the urinary bladder and heart. The ACM has advantages of biological recognition and structural and biochemical similarities with the target tissue that are not easily reproduced using conventional synthetic or tissue-mimicking materials [1]...

This paper examines three bodies of macroscopic evidence that are relevant to testing the classical theory of production. No one of these bodies of evidence offers any persuasive support for the classical theory. Fits to data of the Cobb-Douglas and ACMS functions appear to be artifactual, the data actually reflecting the accounting identity between values of inputs and outputs. Similarly, ther...

Abstract The evolution of manufacturing systems, influenced by changes along four axes - products, technology, business strategies and production paradigms is presented. Adoption human-centric decision making in meshed collaboration with intelligent systems examined. Implications preparedness for the shift towards more responsive, adaptive are reviewed. Research industrial use cases A vision ne...

Abstract Background and aims The Takotsubo syndrome (TTS) is characterised by an acute left ventricular dysfunction without exhibiting signs of stenosis. TTS affects mainly the ventricle, however, its pathophysiology comprises transient impairments in atrium functions with a prevalence atrial fibrillation (AF) around 18% correlating higher heart rhythm disorders. In this study, we aimed to prov...

Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder caused by dysfunction and degeneration of motor neurons. Multiple disease-causing mutations, including in the genes for SOD1 and TDP-43, have been identified in ALS. Astrocytes expressing mutant SOD1 are strongly implicated in the pathogenesis of ALS: we have shown that media conditioned by astrocytes carrying mutant SOD1(G93A) c...

Mutations in the LMNA gene, encoding nuclear envelope proteins lamin A/C, cause cardiac arrhythmias, conduction disease, and dilated cardiomyopathy. Malignant arrhythmias such as atrial fibrillation (AF) ventricular tachycardia are common pose an increased risk of stroke sudden death. To investigate etiological mechanisms by which a heterozygous pathogenic LMNA-S143P mutation causes early-onset...