Wit/i 1/me technical assistance of LOUISE I} s M ORE thami five years have elapsed since the favorable effects of adrenocorticotropic hormomie on the course of acquired autoimmune hemolytic anemia were first recorded.’3 Since then numerous reports have appeared cmicompassimig seties of cases or individual case reports, all in general attesting to the usefulmiess of this form of therapy.422 The ...

The human parvovirus (HPV) is believed to be the causative agent of erythema infectiosum, or fifth disease. 1 Transient aplastic crisis linked to HPV infection has been described in several types of hemolytic anemias, congenital or acquired, such as sickle cell disease, thalassemia, autoimmune hemolytic anemias, and hereditary spherocytosis.2-8 In some instances, the underlying hemolytic anemia...

Bendamustine is an alkylating agent approved for the treatment of chronic lymphocytic leukemia (CLL) and B-cell non-Hodgkin lymphoma. There are scant reports on bendamustine-induced immune hemolytic anemia occurring mainly in CLL patients. We report a case of immune hemolytic anemia that developed after exposure to bendamustine in a 70-year-old female with CLL who was previously exposed to flud...

(Case 1) A 13-years-old female had multiple arthralgia and butterfly rush, when she admitted in our hospital in May 2001. Nephropathy, hemolytic anemia (Hb 6.3 g/dl and direct Coombs 3+) and high titers of antinuclear antibodies and anti-ds-DNA antibody were disclosed and she was diagnosed as systemic lupus erythematosus (SLE). Although combination therapy of PSL 60 mg/day with a steroid pulse ...

Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease characterized by complement overactivation. Inherited defects in complement genes and acquired autoantibodies against complement regulatory proteins have been described. Incomplete penetrance of mutations in all predisposing genes is r...

The use of (51)Cr-labeled red blood cells to determine erythrocyte survival in circulation is not a routine procedure. Data are acquired by frequent counting of small-volume blood samples to determine the rate of red cell survival over time. Results are entirely quantitative and can involve semilogarithmic graphing techniques. An accurate study can positively identify hemolytic anemia, a disord...

REFERENCES 1. Mayer B, Yurek S, Kiesewetter H, Salama A. Mixed-type autoimmune hemolytic anemia: differential diagnosis and a critical review of reported cases. Transfusion 2008;48:2229-34. 2. Sudha Reddy VR, Samayam P, Ravichander B, Bai U. Autoimmune hemolytic anemia: mixed type-a case report. Indian J Hematol Blood Transfus 2011;27:107-10. 3. Hoffman PC. Immune hemolytic anemia-selected topi...

I N 1949, Owren first noted a beneficial effect of heparin therapy in autoimmune hemolytic anemia.1 Dramatic therapeutic responses were subsequently reported by other investigators.26 However, neither the value nor the precise mechanism of action of this drug has been elicited in the treatment of autoimmune hemolytic anemia. We have evaluated the use of parenteral heparin in seven patients with...

hemolytic anemia is exceedingly rare and an underestimated complication after aortic valve replacement (avr).the mechanism responsible for hemolysis most commonly involves a regurgitated flow or jet that related to paravalvar leak or turbulence of subvalvar stenosis. it appears to be independent of its severity as assessed by echocardiography. we present a case of a 24-year-old man with a histo...