G. D. HUNTER AND G. POPJAK I95I James, A. T. & Martin, A. J. P. (1951). Biochem. J. 48, vii. Kao, C. H. & Ma, S. (1931). J. chem. Soc. p. 2046. Kon, G. A. R., Linstead, R. P. & Maclennan, G. W. G. (1932). J. chem. Soc. p. 2454. Lane, J. F. & Wallis, E. S. (1941). J. Amer. chem. Soc. 63, 1674. Oldham, J. W. H. (1950). J. chem. Soc. p. 100. Organic Syntheses (1925). 4, 9. Ponzio, G. (1905). Gazz....

VARIABILITY IN THE PRODUCTION OF FUNGAL SPORES AND IN THE MEASUREMENT OF SPORE YIELDS WAS INVESTIGATED IN FOUR SPECIES OF FUNGI: Colletotrichum gloeosporioides, Colletotrichum coccodes, Colletotrichum phomoides, and Acremonium strictum. When the fungi were grown on solid medium in microplates and spore yields were measured by counting the subsamples with a hemacytometer, the variability among h...

The filamentous fungus Acremonium chrysogenum is the industrial producer of the β-lactam antibiotic cephalosporin C. Here, we present the genome sequence of strain ATCC 11550, which contains genes for 8,901 proteins, 127 tRNAs, and 22 rRNAs. Genome annotation led to the prediction of 42 gene clusters for secondary metabolites.

A case of Acremonium kiliense peritonitis is described. Diagnosis was established by repeated isolation of the fungus from peritoneal dialysate and by its identification on the basis of morphological characteristics and sequencing of internal transcribed spacer (ITS) regions of ribosomal DNA (rDNA). This report and available literature suggest that A. kiliense may have a greater clinical signif...

Isolation and sequencing of a PKS gene isolated from xenovulene-producing cultures of Acremonium strictum indicated the presence of NT-, KS-, AT-, PT-, C-MeT- and R-domains; heterologous expression in Aspergillus oryzae resulted in the production of 3-methylorcinaldehyde, demonstrating the role of the terminal reductase domain in product release.

In a cell-free system prepared by lysis of protoplasts of Cephalosporium acremonium mutant M-0198, isopenicillin N was converted into a penicillinase-resistant material that behaved like deacetoxycephalosporin C on high-pressure liquid chromatography analysis. This activity was found to be unstable to storage at -80 degrees C; 70-80% of the activity was lost after 1 day.