Antibodies elicited in rabbits by immunization with conjugates prepared from serum albumins and nitrogen mustard derivatives of quinacrine (atebrin) were found to have strong binding sites complementary to the quinacrine hapten. The characteristic absorption spectrum of quinacrine made possible accurate determinations of the antigen-antibody composition of the serological precipitates. Conclusi...

A real-time fluorescence assay system using a series of 9-N-(alkylamino)acridine derivatives (methyl, ethyl, n-propyl, n-butyl, n-pentyl, and benzyl) that are N-dealkylated to 9-aminoacridine (9AA) is described. The product, 9AA, is approximately 27-fold more fluorescent than the substrates using excitation and emission wavelengths of 405 and 455 nm, respectively. Tests using expressed CYP1A1, ...

The aim of the work was to establish spect­rum biological activity new derivatives 9-bromo-1,2,3,4-tetrahydroacridine due limi­ted amount literature data. In silico prediction selected bromo-derivatives hydrogenated acridines performed using SuperPred 3.0 web resource. obtained results were compared with active drugs that contain acridine cycle in their structure - Tacrine, Amiridine and Amsacr...