Actinobacteria produce a broad spectrum of bioactive substances that are used in the pharmaceutical, agricultural, and biotechnology industries. This study investigates production Streptomyces, isolated from soil under five tropical plants, focusing on their potential as natural antibacterial dyes for silk fabrics. Out 194 isolates, 44 produced pigments broken rice solid substrate culture. Eigh...

Changing the concentrations of NAD+ and histones did not alter significantly the observed inhibition. However, the inhibition was relieved by increasing amounts of DNA (Fig. 36). The effect of Actinomycin D was further studied by changing the order of addition of the various compounds (Fig. 3c). These results showed that when Actinomycin D was incubated with the polymerase before the addition o...

Previous studies showed that murine polymorphonuclear leukocytes (PMNs) lyze tumour cells in the presence of wheat germ agglutinin or actinomycin D. This paper reports studies on whether a soluble factor participates in PMN-mediated cytolysis dependent on lectin or a chemotherapeutic drug. Tumour lysis was observed with supernatants from PMN cocultured with wheat germ agglutinin or actinomycin ...

The lethal actions of mitomycin C and actinomycin D were followed during the division cycle of HeLa cells. The cells were most susceptible to a 2 hr pulse of mitomycin C during the G(1) phase, whereas their sensitivity to actinomycin D was most pronounced in the S phase. Posttreatment of the cells with acetoxycycloheximide, a potent inhibitor of protein synthesis, increased the survival (colony...