نتایج جستجو برای: activated factor vii

تعداد نتایج: 1036567  

Journal: :Blood 1985
J W Shands

The in vitro production of factor VII-like material and of tissue factor activity by murine thioglycollate exudate macrophages was measured by amidolytic assays. Tissue factor activity was inducible by endotoxin, and its induction was inhibited by 1 microgram/mL of actinomycin D, 10 micrograms/mL of cycloheximide, and 0.2 micrograms/mL of tunicamycin. Soluble factor VII-like material was secret...

Journal: :The Journal of clinical investigation 1956
A J SEAMAN P A OWREN

All reported adsorbents of prothrombin simultaneously adsorb proconvertin, and practically all described techniques of elution have resulted in their simultaneous release from these adsorbents. In this paper we present information about a material selectively removing prothrombin from an eluate containing prothrombin, proconvertin, and hemophilia B factor (PTC, Christmas factor). The substance ...

Journal: :Blood 1993
J H Morrissey B G Macik P F Neuenschwander P C Comp

Although the majority of factor VII (FVII) circulates in the zymogen form, low levels of activated factor VII (FVIIa) have been postulated to exist in plasma and to serve a priming function for triggering of the clotting cascade. However, direct measurement of plasma FVIIa has not previously been possible. We have quantified plasma FVIIa levels using a novel, highly sensitive assay that is free...

Journal: :European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2008
Guillermo Reyes Nieves Carrasco Teresa Muñoz Juan Duarte

Massive pulmonary embolism with concomitant intracranial haemorrhage is a condition associated with high mortality. Emergency embolectomy is indicated in those cases in which medical treatment is not possible. The case of a 65-year-old woman with massive pulmonary embolism after cranial trauma with intracranial haemorrhage and two cardiac arrests prior to surgery is described. The patient suffe...

Journal: :The British journal of ophthalmology 2001
S Kadayifçilar D Ozatli O Ozcebe E C Sener

AIM To determine whether a newly identified thrombophilia factor, activated factor VII (FVIIa), is associated with retinal vein occlusion (RVO). METHODS 54 consecutive cases with RVO seen between March and September 1999 were included in the study. 22 cases had central retinal vein occlusion (CRVO) and 32 had branch retinal vein occlusion (BRVO). Ophthalmoscopic examination with detailed medi...

2009
A Richardson M Herbertson R Gill

Recombinant factor VIIa may reduce surgical blood loss and transfusion of blood products in cardiac surgery. However, the true risks of its use in this setting remains to be elucidated, especially when it is administered with other potent pro-haemostatic agents. We reviewed the recent literature on this topic and suggest that the off label use of recombinant factor VIIa is likely to continue. I...

Journal: :British Journal of Clinical Pharmacology 2008
Thomas Klitgaard Tina G Nielsen

AIMS To review the pharmacokinetics of rFVIIa in various patient populations, and to discuss the differences observed between groups. METHODS Based on a registry of Novo Nordisk studies, 14 studies evaluating rFVIIa pharmacokinetics following single and multiple bolus administration in healthy volunteers, adult and paediatric patients with congenital haemophilia and inhibitors, patients under...

2005
Sudhir Kumar

Acute stroke is the third leading cause of death worldwide, exceeded only by coronary artery disease and cancer. There are two major subtypes of strokeischemic and hemorrhagic with 20-30% of all strokes being hemorrhagic in nature. The incidence of ischemic strokes has steadily declined by virtue of rigorous risk factor modification, but the same has not been possible for hemorrhagic strokes. M...

Journal: :The Israel Medical Association journal : IMAJ 2009
Tzipora Strauss Gili Kenet Irit Schushan-Eisen Ram Mazkereth Jacob Kuint

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