Liver fibrosis is an outcome of many chronic liver diseases and often results in cirrhosis, failure even hepatocarcinoma. Zhuyu zhenggan decoction as a classical traditional Chinese medicine formula used to clinical practice while its mechanism unclear. The aim this study was investigate the anti-fibrosis effect explore molecular mechanisms by combining network pharmacology animal experiment. c...

The original online version of this article (Guo, R., Wang, X., Zhang, R., Shi, H., Qiao, Y., Yun, W., Ge, Lin, Y. and Lei, J. (2015) Response Subcutaneous Xenografts of Endometrial Cancer in Nude Mice to Inhibitors Phosphatidylinositol 3-Kinase/Akt Mitogen-Activated Protein Kinase (MAPK) Pathways: An Effective Therapeutic Strategy for Endometrial Cancer. Journal Therapy, 6, 1083-1092. htt...

the hydrophobic proteins of plant plasma membrane still remain largely unknown.  for example in the arabidopsis genome, receptor-like kinases (rlks) are plasma membrane proteins, functioning as the primary receptors in the signaling of stress conditions, hormones and the presence of pathogens form a diverse family of over 610 genes. a limited number of these proteins have appeard in protein pro...

we have investigated the effect of theophylline on the kinetics of the catalytic subunit of protein kinase and related factors in lung tissue. the results show that the point of highest concentration of the c subunit of protein kinase which is active in casein phosphorylation is at 3h of incubation time, but in the presence of 100 ilg/ inl and 10µg/ml theophylline, this is shifted to i.s and 2....

Background: Peripheral nerve injury (PNI) is a common condition that compromises motor and sensory functions. Peripheral nerves are known to have regenerative capability and the pineal hormone, melatonin, is known to aid nerve regeneration. However, the role of Schwann cells and the pathways involved remain unclear. Thus, the aim of this study is to identify the effects of melatonin on Schwann ...

The original online version of this article (Guo, R., Wang, X., Zhang, R., Shi, H., Qiao, Y., Yun, W., Ge, Lin, Y. and Lei, J. (2015) Response Subcutaneous Xenografts of Endometrial Cancer in Nude Mice to Inhibitors Phosphatidylinositol 3-Kinase/Akt Mitogen-Activated Protein Kinase (MAPK) Pathways: An Effective Therapeutic Strategy for Endometrial Cancer. Journal Therapy, 6, 1083-1092. htt...