A single amino acid mutation near the active site of the CAPN5 protease was linked to the inherited blinding disorder, autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV, OMIM #193235). In homology modeling with other calpains, this R243L CAPN5 mutation was situated in a mobile loop that gates substrate access to the calcium-regulated active site. In in vitro activity assays, ...

Introduction Non infectious uveitis in childhood is a relatively uncommon severe disease, with potential significant long-term complications such as cataract, glaucoma and eventually blindness. For these reasons refractory uveitis usually requires early and aggressive immunosuppressive treatment in order to preserve visual acuity and to prevent the significant morbidity of chronic steroid admin...

BACKGROUND Choroidal neovascularization (CNV) is a rare complication of intermediate uveitis. Risk factors are not well-characterized. Here, we describe a case of peripapillary CNV in a patient with intermediate uveitis and explore the pathophysiology and treatment of this condition. This study is a case report and review of the literature. RESULTS A 15-year-old boy with intermediate uveitis ...

A significant proportion of children with JIA-associated uveitis continue to develop considerable visual complications secondary to uveitis despite progress in establishing screening programmes in most countries [1 4]. The question that remains unanswered is why is there a reluctance to immunosuppress patients with active and potentially sight-threatening uveitis? The answer may be a lack of ro...

purpose: to evaluate the role of anxiety in idiopathic acute anterior uveitis. methods: in this case-control study, three groups including 30 patients with uveitis, 30 patients with conjunctivitis, and 30 healthy controls were enrolled for estimating the anxiety level by employing zung anxiety assessment and a structured clinical interview. t test and chi square test were used for statistical a...

PURPOSE To determine the efficacy and safety of repeated intravitreal and subconjunctival administrations of sirolimus in patients with noninfectious uveitis at 1 year in the Sirolimus as a Therapeutic Approach UVEitis (SAVE) Study. METHODS Open-label, prospective, and randomized interventional clinical trial in which 30 patients with noninfectious intermediate, posterior, or panuveitis were ...

Sarcoidosis is an idiopathic, systemic, non-caseating, granulomatous disease with protean clinical manifestations. This disease is highly prevalent in the southern states of United States of America, especially among African-Americans, but uncommon among Asians. Though sarcoidosis concerns physicians of virtually all specialties, it is particularly important to ophthalmologists since a signific...

In a one-stage, interleukin-2 (IL-2), limiting-dilution analysis, peripheral blood mononuclear cells from patients with uveitis and normal control subjects were assayed for S-antigen specific, tetanus-specific, and in vivo activated helper T cells. Controls subjects consistently demonstrated tetanus-specific responses, but neither in vivo activation nor S-antigen specific helper T cell response...

BACKGROUND The study of corneal endothelium, by specular microscopy, in patients with anterior uveitis has largely been restricted to observations on the endothelial cells. In this prospective study "keratic precipitates" (KP) in different types of uveitis were examined in different stages of the disease process and the endothelial changes occurring in the vicinity of the KP were evaluated in c...

concurrence of interstitial nephritis and uveitis named tubulointestitioal nephritis and uveitis syndrome (tinu) are unusual and uncommon presentations of interstitial nephritis. this syndrome is considered after ruling out other differential diagnoses. a-38-year old man presented with acute renal failure and uveitis. the histologic findings of renal biopsy showed acute tubulointestitioal nephr...