Objective(s): Our previous studies have shown that MgO nanoparticles (MgO NPs) could improve anxiety and reduce pain in animals. In this study, the effect of co administration MgO NPs and vitamin C on anxiety like behavior and nociception in postpartum depression (PPD) model were investigated.Materials and Methods:  Female mice (27 ± 3 g) were divided into groups: two control groups, PPD groups...

background: n-acetylcysteine (nac) has been indicated against experimental seizures, but with relatively inconclusive results. this study was undertaken to evaluate whether nac exerts a dose-dependent anticonvulsant effect and to determine nac safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses. methods: following intraperitoneal (i.p.) administration of ...

objective: pinus eldarica (p. eldarica) is one of the most common pines in iran which has various bioactive constituents and different uses in traditional medicine. since there is no documented evidence for p. eldarica safety, the acute and sub-acute oral toxicities of hydroalcoholic extract of p. eldarica bark were investigated in male and female wistar rats in this study. materials and method...

Contrast media (CM), intravascularly administered in radiodiagnostics to enhance vascular visibility, have as complication the occurrence of acute kidney injury, beginning soon after their administration...

This study intended to assess the efficacy of acute administration of natural honey on cardiac arrhythmias and infarct size when it is used during the normothermic ischemia in isolated rat heart. During 30 min of regional normothermic ischemia followed by 120 min of reperfusion, the isolated hearts were perfused by a modified drug free Krebs-Henseleit solution (control) or the solution containi...

creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. creatine supplements have shown beneficial effects on neurological disorders including parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, alzheimer's disease and stroke. however, the potential benefits of creatine for pati...

objective(s): pregabalin (pgb) is a new antiepileptic drug that has received fda approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. this study was undertaken to evaluate the possible adverse effects of pgb on the muscular system of mice. materials and methods: to evaluate the effect of pgb on skeletal...

introduction: hospital has a complex and special structure and the important question that hospital management facing with is how technology can change structure. in the near future, no factor like it is able to change the structure of organization. this research is a way to know the effect of it on triple dimensions of organization structure includes complexity, formalization, and centralizati...