A 72-year-old man developed acute renal failure after coronary bypass surgery that had been complicated by sternal osteomyelitis caused by the Staphylococcus aureus bacterium. Bacteremia and sepsis were not present. Renal biopsy demonstrated a florid, diffuse, proliferative glomerulonephritis with glomerular immune complex deposition. Management included hemodialysis, prolonged antibiotic thera...

A case of post-streptococcal glomerulonephritis following ear-piercing is reported. It illustrates a rare but life-threatening complication of a cosmetic procedure carried out under unhygienic conditions.

In immune-induced inflammation, leukocytes are key mediators of tissue damage. Since A(2A) adenosine receptors (A(2A)Rs) are endogenous suppressors of inflammation, we examined cellular and molecular mechanisms of kidney damage to determine if selective activation of A(2A)R would suppress inflammation in a rat model of glomerulonephritis. Activation of A(2A)R reduced the degree of kidney injury...

Castleman’s disease (CD) is an uncommon atypical lymphoproliferative disorder with different histological and clinical forms. Patients with the plasma cell type frequently present with systemic symptoms; including fever, weight loss, hemolytic anemia, hypoalbuminemia, hypergammaglobulinemia and increased acute-phase proteins. Renal manifestations like proteinuria or hematuria are common in Cast...

Acute postinfectious glomerulonephritis (PIGN) affects children typically after upper respiratory tract or skin infections with streptococci but can complicate the course of other infections. In children, it is generally a self-limiting disease with excellent prognosis. This paper reports a previously healthy 4-year-old boy who experienced a protracted course of PIGN with persisting episodes of...