MRI provides a sensitive and specific imaging tool to detect acute ischemic stroke by means of a reduced diffusion coefficient of brain water. In a rat model of ischemic stroke, differences in quantitative T1 and T2 MRI relaxation times (qT1 and qT2) between the ischemic lesion (delineated by low diffusion) and the contralateral non-ischemic hemisphere increase with time from stroke onset. The ...

Objective(s) Opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema. In the present study, we investigated whether spontaneously withdrawal syndrome might affect stroke outcomes. Materials and Methods Addiction was induced by progressive incremental doses of morphine over 7 days. Behavioral si...

Stroke is a leading cause of death and disability worldwide. Intravenous administration of alteplase (rtPA) within 4.5 hours of symptom onset is currently the only approved drug treatment of acute ischemic stroke (AIS). Various forms of neuroprotection have proven effective in animal models of acute ischemia, but their translation into successful therapies in human stroke has so far been unsucc...

OBJECTIVE In acute myocardial ischemia changes within the QRS complex can add valuable information to that from the repolarization phase. This study evaluates three angles obtained from the main slopes of the R-wave within the QRS complex to assess acute myocardial ischemia. METHODS The QRS angles, denoted by ØR (R-wave angle), ØU (up-stroke angle) and ØD (down-stroke angle), were evaluated i...

We present a case of left upper extremity paresis secondary to acute brachial artery occlusion in an elderly female with active non-ST segment elevation myocardial ischemia (NSTEMI) in the setting of paroxysmal atrial fibrillation. The patient was initially suspected to have a cerebrovascular attack (CVA); however, computed tomography (CT) head was negative for acute stroke. The diagnosis was c...

Background: Stroke is one of the most disabling diseases worldwide. Herbal medicines, especially lavender, have been used to treat ischemic diseases today.  Objectives: The aim of our study was to investigate the effect of aromatherapy with lavender 10% essential oil on motor function, speech and delirium in acute thrombotic cerebral ischemia patients.  Materials & Methods: In this double bli...

Of 171 patients evaluated prospectively and consecutively for cerebral ischemia, 26 (15%) developed symptoms while hospitalized. Cerebral ischemia complicated operative procedures in 12 patients, unsuccessful cardioversion in one and coronary angiography in another. Twelve patients had apparent cerebral embolism and 14 patients had cerebral thrombosis as a mechanism of their symptoms. Hospitali...

Up to now, over 1,000 experimental treatments found in cells and rodents have been difficult to translate to human ischemic stroke. Since ischemia and reperfusion, two separate stages of ischemic stroke, have different pathophysiological mechanisms leading to brain injury, a combination of protective agents targeting ischemia and reperfusion respectively may obtain substantially better results ...

The Effect of Acute Stroke on Cardiac Functions as Observed in an Intensive Stroke Care Unit • Fifty-two stroke patients, 43 with cerebral ischemia and nine with cerebral hemorrhage, underwent continuous cardiac monitoring in an Intensive Stroke Care Unit shortly after the onset of the acute cerebrovascular accident. In the group of patients with no evidence of pre-existing heart disease, eight...